基质辅助激光解吸电离质谱成像在指纹分析中的研究进展

基质辅助激光解吸电离质谱(MALDI-MS)是一种高灵敏度、高通量、多组分同时分析的软电离质谱技术,可通过对物质分析实现分子结构的确认及物质分布信息的获取,因此在指纹分析中获得越来越多的关注。 本文从条件优化入手,讲述基质优化过程。 接着介绍了MALDI-MS成像(MALDI-MSI)在指纹分析领域具体的应用,在形态分析研究方面,总结其与常规显现方法联用对成像效果的影响、对疑难指纹的图像处理;在化学信息分析研究方面,分别从根据质谱信息分析生活习惯/案前活动、指纹遗留时间和个体同一认定对各研究的优点及局限性进行评述,最后为MALDI-MSI在指纹领域未来发展提出展望。

Progress in Matrix-Assisted Laser Desorption Mass Spectrometry Imaging for Fingerprint Analysis

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a soft ionization mass spectrometry technique with high sensitivity, high throughput and simultaneous analysis of multi-components. It can confirm the molecular structure and obtain the material distribution information through the material analysis and has gained more and more attention in fingerprint analysis. Starting from the condition optimization, this paper describes the process of matrix optimization. Then, the specific application of MALDI-MS imaging (MALDI-MSI) in the field of fingerprint analysis is introduced. In the aspect of morphological analysis, the influence of the combination of MALDI-MSI and the conventional development methods on the imaging effect and the image processing of the difficult fingerprint is summarized. In terms of chemical information analysis and research, the advantages and limitations of each research are reviewed from the perspective of analyzing living habits/pre-crime activities, fingerprint residual time and individual identity based on MS information, and the future development of MALDI-MSI in the field of fingerprint is proposed.