2-氨基-10-羟基-5,10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用

2-氨基-10-羟基-5;10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用;二氢磷杂吖嗪; 吡唑啉酮; 合成; 结构鉴定; 诱变性

Syntheses, Mutagenicity and Application of 2-Amino-10- Hydroxy-5,10-Dihydrophenophosphazine 10-Oxide

10-Hydroxy-5,10-dihydrophenophosphazine 10-oxide reacted with acetyl nitryl, viz.,a mixture of acetic acid and concentrated nitric acid to give 10-hydroxy-2-nitro-5,10-dihydrophenophosphazine 10-oxide(74%) which can be further hydrogenated to 2-amino-10-hydroxy-5,10-dihydrophenophosphazine 10-oxide(70%) at pH=7 over 5%Pd/C.The resulting nonmutagenic amino compound(via Salmonella/mammalian microsome assay) was employed as diazo moiety to couple with 3 intermediates containing pyrazolone nucleus to give three different azo dyes.From the investigations of the visible spectra and colorization performances of these azo dyes,it was found that they had deep coloring effects on dyeing wool or silk.In addition,the structures of two intermediates and three azo dyes prepared in this study were determined with spectroscopic techniques.