有机锡配合物{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2的合成、结构和性质研究

二(o-甲基苄基)二氯化锡与N-(o-甲基苄基)羟胺在碱性条件下反应，合成了有机锡配合物{(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2。经X-射线衍射方法测定了化合物的晶体结构。该化合物晶体属三斜晶系，空间群P-1，晶体学参数 a =1.0604(5) nm，b =1.3078(7) nm，c = 1.3742(47 nm，α=105.174(12)?，β = 90.229(7)?，γ=101.028(6)?，Z = 1，V =1.8025(15) nm3，Dc=1.522Mg?m-3，?(MoKa)= 1.423 mm-1，F(000)= 834，R1=0.0455，wR2=0.1017。化合物是三个以Sn2O2构成的平面四元环组成的梯状结构，锡原子均为五配位的畸变三角双锥构型。测定了配合物的体外抗癌活性,结果表明配合物对WiDr和MCF-7等癌细胞有一定的抑制能力。

Synthesis, Crystal Structure and Properties of Organotin Compound{[(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2

The organotin compound {(o-MeC6H4CH2)2Sn(O)]2(o-MeC6H4CH2NHO)}2 was synthesized by the reaction of di(o-methylbenzyl)tin dichloride with N-(o-methylbenzyl)hydroxylamine. It’s structure has been determined by X-ray single crystal diffraction. Crystallorgaphic for the compound: Triclinic, P-1, a =1.0604(5) nm，b =1.3078(7) nm，c = 1.3742(47 nm，α=105.174(12)?，β = 90.229(7)?，γ=101.028(6)?，Z = 1，V =1.8025(15) nm3，Dc=1.522Mg?m-3，?(MoKa)= 1.423 mm-1，F(000)= 834，R1=0.0455，wR2=0.1017. In the compound, the tin ions are five-coordinated and exhibit distorted trigonal bipyramidal geometries.The complrx has a ladder-like structure, which is composed by three Sn2O2 planes. The brief investigation shows that this tin compound is antitumour activity in vitro against WiDr and MCF-7 tumour cells.