| 手性铜催化剂的制备及在环丙烷羧酸酯不对称合成中的应用 |
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| 引用本文： | 杨智才,张小微,陈良.手性铜催化剂的制备及在环丙烷羧酸酯不对称合成中的应用[J].应用化学,1994,0(2):70-72. |
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| 作者姓名： | 杨智才 张小微 陈良 |
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| 作者单位： | 华东师范大学化学系 上海 200062 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 3类手性配体d-10-樟脑磺酸及其衍生物,α-(-)-羟蒎酮及其衍生物,双唑啉衍生物分别与铜(Ⅱ)形成手性铜配合物,催化重氮乙酸酯与1,1-二苯乙烯或异丁烯的环丙烷化加成反应,得到光学活性环丙烷羧酸酯,不对称诱导最高可达95%e.e。
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| 关 键 词： | 重氮乙酸酯 二苯乙烯 异丁烯 环丙烷化 樟脑磺酸 羟蒎酮 双唑啉 手性铜催化剂 |
| 收稿时间： | 1993-03-02 |
| 修稿时间： | 1993-10-20 |
Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters |
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| Yang Zhicai,Zhang Xiaowei,Chen Liang.Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters[J].Chinese Journal of Applied Chemistry,1994,0(2):70-72. |
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| Authors: | Yang Zhicai Zhang Xiaowei Chen Liang |
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| Institution: | Department of Chemistry, East China Normal University, Shanghai 200062 |
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| Abstract: | Three kinds of optically active ligands were combined with copper(Ⅰ)-acetate to give 8 chiral copper complexes:d-camphor-10-sulfonic acid and its derivatives of Schiff base, hydroxypinocamphone and its derivatives of Schiff base,and bis-oxazoline. The optical yields of 2,2-diphenylcyclopropanecarboxylic ethyl ester were 5%～50e.e.. The reaction of diphenylethylene or isobutylene with menthyl diazoaceteta by chiral copper(Ⅰ) bis-oxazo-line gave an enantioselectivity of 81.5%e.e. and 95%e.e., respectively. |
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| Keywords: | diazoacetate diphenyl ethylene isobutylene cyclopropanation camphorsulfonicacid hydroxypinocamphone bisoxazoline chiral copper complex |
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