微波促进下4-芳基亚氨基-1,2,4-三唑的合成

无溶剂;无催化剂;微波辐射;取代基-巯基-芳基亚氨基三唑

Synthesis of 4-Arylideneamino-1,2,4-triazoles under Microwave Irradiation

Microwave-assisted synthesis of nine 4-arylideneamino-5-mercapto-3-substituted-4H-1,2,4-triazoles via the reaction of 4-amino-5-mercapto-3-substituent-1,2,4-triazoles with arylaldehydes under solvent-free conditions without catalyst was completed. The reactants were mixed in an equal molar ratio, and exposed to MW irradiation for 9 -10 min, and the yields were 81% -92%. The mercapto group did not react with the imine group to give the products with two heterocycles. This method avoids the long reaction time of usual synthesis route using ethanol as solvent and acid as catalyst, and saved the troubles of using acetic acid as solvent and catalyst. The structures of the products were confirmed by ^1H NMR and IR.