| 苯并吡喃-4-脲、硫脲和氰胍类化合物的合成及其血管舒张活性 |
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| 引用本文： | 赵圣印,黄文龙,张惠斌,周金培.苯并吡喃-4-脲、硫脲和氰胍类化合物的合成及其血管舒张活性[J].应用化学,2002,19(12):1128-0. |
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| 作者姓名： | 赵圣印 黄文龙 张惠斌 周金培 |
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| 作者单位： | 中国药科大学 |
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| 基金项目： | 国家自然科学基金资助项目 ( 39370 811) |
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| 摘 要： | 钾通道开放剂;苯并吡喃-4-脲、硫脲和氰胍类化合物的合成及其血管舒张活性
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| 关 键 词： | 钾通道开放剂 苯并吡喃-4-脲、硫脲和氰胍类化合物的合成及其血管舒张活性 |
| 文章编号： | 1000-0518(2002)12-1128-05 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2002年5月23日 |
Synthesis and Vasorelaxant Activity of Benzopyran-4- urea, -thiourea, and -cyanoguanidine Derivatives as K+ Channel Openers |
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| ZHAO Sheng-Yin,HUANG Wen-Long ,ZHANG Hui-Bin,ZHOU Jin-Pei.Synthesis and Vasorelaxant Activity of Benzopyran-4- urea, -thiourea, and -cyanoguanidine Derivatives as K+ Channel Openers[J].Chinese Journal of Applied Chemistry,2002,19(12):1128-0. |
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| Authors: | ZHAO Sheng-Yin HUANG Wen-Long ZHANG Hui-Bin ZHOU Jin-Pei |
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| Institution: | ZHAO Sheng-Yin,HUANG Wen-Long *,ZHANG Hui-Bin,ZHOU Jin-Pei |
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| Abstract: | Seventeen benzopyran-4-urea, -thiourea and -cyanogunidine derivatives were synthesized as K + channel openers. Their structures were confirmed by IR, 1H NMR, MS and elemental analysis. Their vasorelaxant activities againat low (30 mmol/L ) KCl-induced contraction were preliminary evaluated on rat aorta in vitro. Some compounds synthesized(7c, 8a, 8b and 8c) were found exhibited some, but less, low concentration K +(30 mmol/L KCl) channel opening activity than Emakalim. |
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| Keywords: | benzopyran K + channel opener synthesis vasorelaxant activity |
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