乙基二茂铁与乙酰丙酸甲酯的缩合反应

以多聚磷酸-浓硫酸-甲醇为催化剂和环已烷为溶剂,由乙基二茂铁与乙酰丙酸甲酯缩合合成4,4-双（乙基二茂铁基）成酸甲酯,转化率73%,产率84%。正交实验法获得的适宜反应条件：乙基二茂铁55mmol,乙酰丙酸甲酯75mmol,浓硫酸3.0mL,环已烷20mL,甲醇11mL。通过元素分析、IR、^1H NMR和^13C NMR确证了缩合产物的结构。

Condensation of Ethylferrocene with Methyl Levulinate

Condensation of ethylferrocne with methyl levulinate was carried out in cyclohexane and catalyzed by PPA-H 2SO 4-CH 3OH to give methyl 4,4-bis(ethylferrocenyl) pentanate with conversion of 73% and the yield of 84%. The suitable reagent compositions obtained through orthogonal factorization method were 55 mmol ethyferrocene, 75 mmol methyl levulinate, 3 0 mL concentrated H 2SO 4, 20 mL cyclohexane and 11 mL of methanol. The structures of the compounds have been characterized by elemental analysis, IR, 1H NMR and 13 C NMR.