| 4-羟基-3-(2-亚氨基乙基)-2H-苯并吡喃-2-酮类化合物的超声辐射合成 |
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| 引用本文： | 王慧彦,周丹丹,陈秭君.4-羟基-3-(2-亚氨基乙基)-2H-苯并吡喃-2-酮类化合物的超声辐射合成[J].应用化学,2013,30(2):153-158. |
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| 作者姓名： | 王慧彦 周丹丹 陈秭君 |
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| 作者单位： | (1.淮海工学院化学工程学院 连云港 222005；;
2.江苏省有机合成重点实验室， 苏州大学材料与化学化工学部 苏州 215123) |
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| 基金项目： | 淮海工学院大学生创新实验项目，江苏省普通高校研究生科研创新计划资助项目 |
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| 摘 要： | 以乙醇为溶剂,4-羟基-3-乙酰基香豆素和胺为原料,对甲苯磺酸为催化剂,在超声波作用下合成一系列4-羟基-3-(2-亚氨基乙基)-2H-苯并吡喃-2-酮类化合物,产率62%～94%。对产物进行了IR、1H NMR及HRMS表征,对化合物3c进行了X射线衍射分析。该方法具有反应产率高、时间短、反应条件温和及操作简单等优点。
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| 关 键 词： | Schiff 碱 羟基乙酰基香豆素 超声辐射 合成 |
| 收稿时间： | 2012-04-01 |
| 修稿时间： | 2012-07-10 |
Synthesis of 4-Hydroxy-3-(2-imino ethyl)-2H-chromen-2-one Derivatives under Ultrasound Irradiation |
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| WANG Huiyan
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ZHOU Dandan
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CHEN Zijun.Synthesis of 4-Hydroxy-3-(2-imino ethyl)-2H-chromen-2-one Derivatives under Ultrasound Irradiation[J].Chinese Journal of Applied Chemistry,2013,30(2):153-158. |
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| Authors: | WANG Huiyan ZHOU Dandan CHEN Zijun |
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| Institution: | (1.Department of Chemical Engineering,Huaihai Institute of Technology,Lianyungang 222005,China;
2.Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,;
Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China) |
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| Abstract: | A series of 4-hydroxy-3-(2-imino ethyl)-2H-chromen-2-ones was first synthesized by the reaction of 4-hydroxy-3-acetyl coumarin and amines in alcohol with 4-methylbenzenesulfonic acid as catalyst under ultrasonic irradiation. The yields were in the range of 62%~94%. The structures of the products were confirmed by IR, 1H NMR and HRMS. The structure of compound 3c was determined by X-ray single crystal diffractions. The advantages of this method are high yield, shorter reaction time, mild condition and simple work-up procedures. |
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| Keywords: | Schiff base acetyl-hydroxy-2H-chromen-one ultrasonic irradiation synthesis |
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