| 聚乳酸载力福平微球底制备及其释药性能 |
| |
| 引用本文： | 李良,李国明,黎茂荣,容品加.聚乳酸载力福平微球底制备及其释药性能[J].应用化学,2003,20(1):65-68. |
| |
| 作者姓名： | 李良 李国明 黎茂荣 容品加 |
| |
| 作者单位： | 华南师范大学 |
| |
| 摘 要： | 药物释放;聚乳酸载力福平微球底制备及其释药性能
|
| 关 键 词： | 药物释放 聚乳酸载力福平微球底制备及其释药性能 |
| 文章编号： | 1000-0518(2003)01-0065-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2002年6月19日 |
Preparation of Polylactic Acid Encapsulated RFP Microspheres and Drug-Releasing Performance |
| |
| Abstract: | Polylactic acid(PLA) microspheres(MS) were prepared by an oil-in-water solvent evaporation method to encapsulate rifampin(RFP). Effects of molecular weight of PLA, the drug content, microsphere size, pH value of medium on the drug-releasing performance of the PLA microspheres were investigated. The results showed that the greater the molecular weight of PLA, the less it degrades and the more slowly the drug release. Again, the greater the content of RFP and the greater the difference of drug concentration between in and out of the microsphere, the more quickly the drug releases. The smaller the microsphere size, the more quickly the drug releases. In the alkali medium, the PLA degrades more quickly, and RFP becomes more stable, resulting in the faster release of drug. |
| |
| Keywords: | polylactic acid microsphere refampin drug release |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
| 点击此处可从《应用化学》下载免费的PDF全文 |
|
