| 淀粉基荧光微球的制备及其布洛芬包载和释药性能 |
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| 引用本文： | 李洋,宁志刚,谭颖,孙淑苗,王丕新.淀粉基荧光微球的制备及其布洛芬包载和释药性能[J].应用化学,2011,28(10):1114-1121. |
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| 作者姓名： | 李洋 宁志刚 谭颖 孙淑苗 王丕新 |
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| 作者单位： | (1.长春工业大学化学与生命科学学院 长春；
2.中国科学院长春应用化学研究所生态环境高分子材料实验室 长春 130022) |
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| 基金项目： | 国家自然科学基金资助项目(21004065,51073153) |
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| 摘 要： | 以淀粉为原料，用乙酸酐酰化后，将异硫氰酸荧光素（FITC）接枝到淀粉醋酸酯大分子链上，以自组装的方法制备出包载布洛芬的淀粉基荧光微球，同时考察了淀粉基荧光纳米微球对布洛芬的控制释放性能。 荧光淀粉酯的用量、布洛芬的加入量及丙酮与水的体积比可影响载药微球的包封率和药物释放速度。 研究结果表明，当荧光淀粉酯用量为200 mg、布洛芬的量为60 mg、水和丙酮体积分别为50和20 mL时所合成的载药微球包封率最高，为69.5%，其药物体外释放也最快，48 h可释放62.7%。 用扫描电子显微镜和激光共聚焦显微镜(CLSM)对包药微球的体外释放过程进行了表征。
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| 关 键 词： | 淀粉 荧光微球 布洛芬 包封率 体外释放 |
| 收稿时间： | 2010-11-24 |
| 修稿时间： | 2011-01-12 |
Preparation and Drug-release Properties of Ibuprofen-loaded and Fluorescein-labeled Starch-based Nanospheres |
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| LI Yang,NING Zhigang,TAN Ying,SUN Shumiao,WANG Pixin.Preparation and Drug-release Properties of Ibuprofen-loaded and Fluorescein-labeled Starch-based Nanospheres[J].Chinese Journal of Applied Chemistry,2011,28(10):1114-1121. |
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| Authors: | LI Yang NING Zhigang TAN Ying SUN Shumiao WANG Pixin |
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| Institution: | (1.School of Chemistry and Life Science,Changchun University of Technology,Changchun;
2.Key Laboratory of Ecomaterial Polymers,Changchun Institute of ;
Applied Chemistry,Chinese Academy of Sciences,Changchun 130022) |
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| Abstract: | Starch was firstly acylated by acetic anhydride,fluorescein isothiocyanate(FITC) was then covalently attached onto the starch acetate.And the fluorescein-labeled starch acetate could self-assemble to form uniform nanospheres encapsulated with ibuprofen.The controlled-release properties of obtained ibuprofen-loaded fluorescein-labeled starch nanospheres were investigated in details.The amounts of drug-loading and release rate could be tuned by changing the amounts of fluorescein-labeled starch acetate,ibupro... |
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| Keywords: | starch fluorescein nanosphere ibuprofen encapsulation efficiency drug release |
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