| 5-氨基-6-硝基-[1,2,5]噁二唑并[3,4-b]吡啶-1-氧化物的新法合成 |
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| 引用本文： | 董岩,刘祖亮,袁成梁.5-氨基-6-硝基-[1,2,5]噁二唑并[3,4-b]吡啶-1-氧化物的新法合成[J].应用化学,2011,28(5). |
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| 作者姓名： | 董岩 刘祖亮 袁成梁 |
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| 作者单位： | 南京理工大学化工学院,南京,210094 |
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| 摘 要： | 以2,6-二氯吡啶为起始原料,经肼基化、还原、硝化、Nietzki-Dietschy环合4步反应得到5-氨基-6-硝基-1,2,5]噁二唑并3,4-b]吡啶-1-氧化物.结合反应机理讨论了还原、硝化、Nietzki-Dietschy环合反应的影响因素,获得了合成-.氨基-6-硝基-1,2,5]噁二唑并3,4-b]吡啶-1-氧化物的最佳工艺条件,目标产物的总收率为59.2%.用1H NMR、MS和IR谱对5-氨基-6-硝基-1,2,5]噁二唑并3,4-b]吡啶-1-氧化物的结构进行了表征.
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| 关 键 词： | 二氯吡啶 氨基硝基-[1 2 5]噁二唑并[3 4-b]吡啶氧化物 盐酸羟胺 超酸硝化 Pd/C-H2还原 合成 |
A New Synthetic Route to 5-Amino-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-1-oxide |
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| DONG Yan,LIU Zuliang,YUAN Chengliang.A New Synthetic Route to 5-Amino-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-1-oxide[J].Chinese Journal of Applied Chemistry,2011,28(5). |
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| Authors: | DONG Yan LIU Zuliang YUAN Chengliang |
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| Institution: | DONG Yan,LIU Zuliang,YUAN Chengliang(Chemical Engineering School,Nanjing University of Science & Technology,Nanjing 210094) |
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| Abstract: | A new synthetic route to 5-amino-6-nitro- oxadiazolopyridine-1-oxide was developed using 2,6-dichloropyridine as starting materials via four steps,including hydrazinolysis,reduction,nitration and Nietzki-Dietschy cyclization.The effects of these reactions were investigated based on their reaction mechanisms.On the basis of these results,the reaction was optimized and the overall yield of target product was up to 59.2%.The product was characterized by 1HNMR,MS and IR. |
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| Keywords: | dichloropyridine amino nitro-oxadiazolopyridine-oxide hydroxylamine hydrochloride super acid nitration Pd/C-H2 reduction synthesis |
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