| 微量热法研究硒代吗啉衍生物的抑菌作用 |
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| 引用本文： | 李曦,刘义,吴军,屈松生.微量热法研究硒代吗啉衍生物的抑菌作用[J].应用化学,2002,19(7):645-0. |
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| 作者姓名： | 李曦 刘义 吴军 屈松生 |
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| 作者单位： | 武汉理工大学，武汉大学 |
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| 基金项目： | 国家自然科学基金 (2 9973 0 3 0 )资助项目 |
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| 摘 要： | 大肠杆菌;生长代谢;微量热法研究硒代吗啉衍生物的抑菌作用
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| 关 键 词： | 大肠杆菌 生长代谢 微量热法研究硒代吗啉衍生物的抑菌作用 |
| 文章编号： | 1000-0518(2002)07-0645-04 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2001年11月15 |
Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli |
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| LI Xi a,b,LIU Yi b,WU Jun b,QU Song Sheng b.Microcalorimetric Study on the Action of Selenomorpholine Derivatives on Growth Metabolism of Escherichia coli[J].Chinese Journal of Applied Chemistry,2002,19(7):645-0. |
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| Authors: | LI Xi a b LIU Yi b WU Jun b QU Song Sheng b |
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| Institution: | LI Xi a,b*,LIU Yi b,WU Jun b,QU Song Sheng b |
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| Abstract: | The inhibitory or antibiotic actions of three kinds of the selenomorpholine derivatives on a strain of Escherichia coli have been studied by microcalorimetry. Differences in their abilities to inhibit the metabolism of this bacteria were observed. The extent and level of the inhibitory effect on the metabolism as judged by the rate constant, k , and the half inhibitory concentration, IC 50 , varied with the kinds of drugs. The rate constant( k ) of Escherichia coli in the presence of the drugs was found decreased with the increase in concentration of the drug. The experimental results revealed that the antibiotic activity of selenomorpholines was in order of: N dodecyl selenomorpholine acetyl methyl ester bromide> N dodecyl selenomorpholine> 4 selenomorpholine formyl ethyl ester. |
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| Keywords: | selenomorpholine derivative Escherichia coli metabolism inhibition microcalorimetry |
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