COMSOL软件在枸杞多糖超滤膜生物反应器中膜阻塞模型构建中的应用

基于聚砜中空纤维超滤膜分离技术精制枸杞多糖（Lycium barbarum polysaccharide），通过COMSOL软件对枸杞多糖膜阻塞逆流提取及超声设备参数进行修正，获得更优的纯化工艺。采用微波-超声法提取枸杞多糖，并利用聚砜中空纤维超滤膜对枸杞多糖进行分离，采用单因素分析及正交实验考察枸杞多糖提取和分离过程中的重要参数，通过COMSOL软件对重要膜阻塞参数进行修正。结果表明，枸杞多糖提取较优工艺条件为：提取温度50~70 ℃之间，超声功率50 W，固液比例1∶8~1∶12（mg∶mL），提取时间40~60 min；当超滤膜截留相对分子质量为1×10⁴时，膜通量较好；正交实验结果表明，膜通量与料液温度关系最大，其次是膜pH值和分离操作压；COMSOL软件对枸杞多糖连续逆流提取设备进行仿真计算，结果发现与全封闭叶片相比，开孔叶片能够显著降低溶剂短路现象，使得最低流速提升高达65倍。基于COMSOL软件数据修订，枸杞多糖分离效率得到大幅度提升，为枸杞多糖工业化生产提供必要的数据积累。

Study on Membrane Blocking in Lycium Barbarum Polysaccharide Ultrafiltration Membrane Bioreactor Based on COMSOL Software

Lycium barbarum polysaccharide is refined based on polysulfone hollow fiber ultrafiltration membrane separation technology， and the lycium barbarum polysaccharide membrane blocking countercurrent extraction and ultrasonic equipment parameters are corrected by COMSOL software to obtain a better purification process. A microwave-ultrasonic method is used to extract Lycium barbarum polysaccharides， and polysulfone hollow fiber ultrafiltration membranes are used to separate Lycium barbarum polysaccharides. Single factor analysis and orthogonal experiments are used to investigate the important parameters in the extraction and separation process of Lycium barbarum polysaccharides. The important membrane blocking parameters are corrected by the COMSOL software. The optimal process conditions for the extraction of Lycium barbarum polysaccharides are： the extraction temperature between 50~70 ℃， ultrasonic power 50 W， solid-liquid ratio 1∶8~1∶12， and extraction time 40~60 min. When the ultrafiltration membrane relative molecular weight cut-off is 1×10⁴， the membrane flux is better. The orthogonal experiment results show that the membrane flux has the largest relationship with the temperature of the feed liquid， followed by the membrane pH value and separation operating pressure. COMSOL software performs continuous countercurrent extraction equipment for Lycium barbarum polysaccharides and the calculations show that compared with fully enclosed blades， perforated blades can significantly reduce the solvent short-circuit phenomenon and increase the minimum flow rate by up to 65 times. The COMSOL software performs simulation calculations on the ultrasonic equipment. When the double ultrasonic transducers are axially separated by 12 cm， the axis crosses 90（°） and the power is set to 50 W， the regional mass transfer flux can be significantly increased. Based on the revision of COMSOL software data， the separation efficiency of Lycium barbarum polysaccharides has been greatly improved， which provides necessary data accumulation for the industrial production of Lycium barbarum polysaccharides in the future.