联苯并咪唑化合物的合成、表征与抗癌活性

以联苯四胺、芳香醛为原料,DMF为溶剂,KI为催化剂,在空气存在下回流反应,合成了6种新的联苯并咪唑化合物,产率较高(58.4%～98.0%),其结构用IR、1HNMR、13CNMR、MS、元素分析等测试技术进行了表征。适宜的合成条件是:反应温度150℃,反应时间12h。初步测试表明,目标化合物对培养人肝癌Bel-7402细胞生长有一定抑制活性。

Synthesis and Characterizations of Bisbenzimidazoles and Their Anti-cancer Activities

Using DMF as solvent, 3,3′-diaminobenzidine and aromatic aldehydes as starting materials, and KI as catalyst, six new bisbenzimidazoles were synthesized in the presence of air. The structures of the compounds were characterized by means of FTIR, ¹H NMR, ¹³C NMR, MS and elemental analysis. The optimal synthetic conditions were investigated. When the temperature was 150 ℃ and the reaction time was 12 h, the six compounds were obtained with yields in the range of 58.4% to 98.0%. The new method with readily available catalyst is advantageous to conventional synthetic process of bisbenzimidazoles due to its less steps, simpler operations, easier post processings and higher yields. The anti-tumor activities of the target compounds were preliminarily examined via MTT method on Bel-7402 cell in vitro, and they exhibited certain inhibition activities.