甲胺基阿维菌素苯甲酸盐微胶囊的制备与表征

以三聚氰胺-甲醛树脂为壁材,采用原位聚合法制备了甲胺基阿维菌素苯甲酸盐微胶囊,研究了三聚氰胺与甲醛的质量比、芯壁比、乳化剂、搅拌速度与时间、pH值、温度等因素对微胶囊形成的影响,对制备的微胶囊进行了表征,测定了甲维盐微胶囊化前后的光解率。结果表明,三聚氰胺与甲醛质量比为1∶2、芯材与壁材质量比为3∶2、以质量分数1%羟乙基纤维素(HEC)为乳化剂、在1000r/min搅拌速度下、pH=5.0和50℃保温2h可制备出形貌较好、平均粒径4.4μm的甲维盐微胶囊。红外光谱分析证明,甲维盐已完全被包覆在微胶囊中。紫外分光光度法测定其缓释性能良好。光解实验表明,微胶囊化可有效降低甲维盐原药的光解。

Preparation and Characterization of Emamectin Benzoate Microcapsules

Using formaldehyde and melamine as wall materials, encapsulated emamectin benzoate-toluene microcapsules were prepared via an in-situ polymerization process. The experimental results show that well defined microcapsules with uniform particle size around 4.4 μm could be formed when the mass ratio of melamine to formaldehyde is 1∶2, core to wall is 3 to 2, using 1% mass fraction of HEC as emulsifying agent, the stirring ratio is 1000 r/min, pH value is 5.0, the temperature and heating time are 50 ℃ and 2 h, respectively. An improved photodegradation of emamectin benzoate microcapsules toward UV light could be achieved. Fourier-transform infrared spectroscopy(FT-IR) results also demonstrate the successful encapsulation of emamectin benzoate within the wall material.