| 3-氨基-2-羟基-4-苯基丁酸的合成 |
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| 引用本文： | 刘晓玲,林淑英,盛寿日,辛勤,宋才生.3-氨基-2-羟基-4-苯基丁酸的合成[J].应用化学,2005,22(2):222-0. |
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| 作者姓名： | 刘晓玲 林淑英 盛寿日 辛勤 宋才生 |
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| 作者单位： | 江西师范大学化学化工学院,南昌,330027 |
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| 基金项目： | 江西省教育厅科技项目(赣财教[2003]73号)资助 |
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| 摘 要： | 3-氨基-2-羟基-4-苯基丁酸的合成;乌苯美司;氨基羟基苯基丁酸;合成
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| 关 键 词： | 3-氨基-2-羟基-4-苯基丁酸的合成 乌苯美司 氨基羟基苯基丁酸 合成 |
| 文章编号： | 1000-0518(2005)02-0222-02 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2004年3月30日 |
Synthesis of 3-Amino-2-hydroxy-4-phenylbutanoic Acid |
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| LIU Xiao-Ling,LIN Shu-Ying,SHENG Shou-Ri ,XIN Qin,SONG Cai-Sheng.Synthesis of 3-Amino-2-hydroxy-4-phenylbutanoic Acid[J].Chinese Journal of Applied Chemistry,2005,22(2):222-0. |
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| Authors: | LIU Xiao-Ling LIN Shu-Ying SHENG Shou-Ri XIN Qin SONG Cai-Sheng |
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| Institution: | LIU Xiao-Ling,LIN Shu-Ying,SHENG Shou-Ri *,XIN Qin,SONG Cai-Sheng |
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| Abstract: | Amino-2-hydroxy-4-phenylbutanoic acid(compound 3), the key intermediate for the synthesis of Bestatin, was prepared via substitution, condensation and reduction in an overall yield of about 47.8%. The reaction of nitromethane with benzyl bromide in the presence of sodium ethoxide gave a 82% yield of 1-nitro-2-phenylethane(compound 1). The condensation of compound 1 with glyoxylic acid monohydrate in sodium ethoxide/ethanol afforded a 72% yield of 3-nitro-2-hydroxy-4-phenylbutyric acid(compound 2), which was hydrogenated to compound 3 with a 81% yield in acetic acid in the presence of Pd/C. All the compounds were characterized by 1H NMR, IR and elemental analysis. |
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| Keywords: | Bestatin aminohydroxyphenylbutanoic acid synthesis |
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