1-[(6-烷(苄)氧基-3,4-亚甲二氧基)苯基]-2-(1H-1,2,4-三唑)-乙酮(醇)类化合物的合成及抑菌活性

为了寻找新的低毒高效杀菌剂，以芝麻酚和1-H-1,2,4-三唑为主要原料，合成了12个1-6-烷(苄)氧基-3,4-二氧亚甲基）苯基] -2 -(1H-1,2,4-三唑)-乙酮(醇)类化合物。所有化合物的结构经IR, 1HNMR, 13C NMR确证。初步生物测试结果表明：在质量浓度为100μgmL下，化合物Ⅴc对小麦赤霉病菌的抑制率达到了81.3%；化合物Ⅳe对马铃薯干腐病菌的抑制率达到了83.4%；化合物Ⅴe,Ⅴf对玉米弯孢病菌的抑制率也分别达到了79.7%和72.4%；化合物Ⅳd对小麦赤霉病菌和马铃薯干腐病菌的抑制率分别达到了68.9%和65.7%。

Study on Synthesis and fungicidal activity of 1-[6-alkoxy(benzyloxy) -3,4-methylenedioxyphenyl]-2-(1H-1,2,4-triazole-1-yl)- enthone(ol) compounds

In order to find a novel class of low toxic and high-efficiency fungicides, 12 1-6-alkoxy (benzloxy)-3,4-methylenedioxyphenyl]-2-(1H-1,2,4-triazole-1-yl)-enthone(ol) compounds were prepared from sesamol and 1-H-1,2,4-triazole. The structures of all the compounds were confirmed by IR ,1H-NMR,13C-NMR. The preliminary bioassary showed that at the concentration of 100μg/mL, the inhibitory rate of compounds Ⅴc to Fusarium graminearum was 81.3%;Ⅳe to Fusarium oxysporium was 83.4%;Ⅴe and Ⅴf to Cercospora sorghi were 79.7% and 72.4% respectively; Ⅳd to Fusarium graminearum and Fusarium oxysporium were 68.9% and 65.7% respectively.