| 以CyClo（L—Phe—L—His）催化的芳香氰醇不对称合成 |
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| 引用本文： | 童跃进,丁孟贤.以CyClo（L—Phe—L—His）催化的芳香氰醇不对称合成[J].应用化学,1990,7(1):23-27. |
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| 作者姓名： | 童跃进 丁孟贤 |
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| 作者单位： | 中国科学院长春应用化学研究所，中国科学院长春应用化学研究所 长春 130022，长春 130022 |
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| 摘 要： | 以改进的方法合成了环状二肽(CycloL-Phe-L-His),它在苯甲醛和间苯氧基苯甲醛的不对称氰醇化反应中显示了高活性和高对映选择性。研究了各种反应条件对该催化剂活性和选择性的影响,考察了催化剂的回收使用,旋光稳定性和化学稳定性,探索了催化剂结构与性能间的关系。
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| 关 键 词： | 旋光性氰醇 环状二肽 不对称合成 |
| 收稿时间： | 1989-04-18 |
ASYMMETRIC SYNTHESIS OF AROMATIC CYANOHYDRINS CATALYSED BY CYCLO(L-Phe-L-His) |
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| Tong Yuejin,Ding Mengxian Changchun Institute of Applied Chemistry Academia Sinica Changchun.ASYMMETRIC SYNTHESIS OF AROMATIC CYANOHYDRINS CATALYSED BY CYCLO(L-Phe-L-His)[J].Chinese Journal of Applied Chemistry,1990,7(1):23-27. |
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| Authors: | Tong Yuejin Ding Mengxian Changchun Institute of Applied Chemistry Academia Sinica Changchun |
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| Institution: | Tong Yuejin;Ding Mengxian Changchun Institute of Applied Chemistry Academia Sinica Changchun 130022 |
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| Abstract: | Cyclo(L-Phe-L-His) prepared by a modified procedure showed high activity. and enan-tioselectivity in the asymmetric synthesis of aromatic Cyanohydrins from benzaldehyde andm-phenoxybenzaldehyde. The influence of the reaction conditions on the activity and sele-ctivity of the dipeptide has been investigated. The cyclodipeptide can be easily recoveredand reused without any loss of the catalytic activity. The optical and chemical stabilityas well as the relationship between the aggregation and properties of the catalyst have beendiscussed. |
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| Keywords: | optically active cyanohydrin cyclic dipeptide asymmetric synthesis |
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