（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶的制备及其释药作用

将壳聚糖改性为（2-羟基-3-丁氧基）丙基 羟丙基壳聚糖（2-H-3-B-P-HPCS），并以（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖和聚乙二醇（PEG）为原料制备（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶，研究了（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖浓度、聚乙二醇的用量、交联剂戊二醛用量、反应温度对该凝胶溶胀性能的影响。 通过红外光谱分析和扫描电子显微镜的方法比较了壳聚糖、（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖和（2-羟基-3-丁氧基）丙基-羟丙基壳聚糖/聚乙二醇互穿网络凝胶结构和形态上的不同。 以阿昔洛韦为模型药物研究了其释药性能。 结果表明，该凝胶均具有良好的溶胀性、pH敏感性和药物缓释作用，有望用作新型的药物载体。

Preparation and Drug Release Behavior of Interpenetrating Polymer Network Hydrogel of Polyethylene Glycol and (2-Hydroxy-3-butoxy)propyl Hydroxypropyl Chitosan

(2-Hydroxy-3-butoxy)propyl hydroxypropyl chitosan (2-H-3-B-P-HPCS) was synthesized to prepare 2-H-3-B-P-HPCS/polyethylene glycol (2-H-3-B-P-HPCS/PEG) interpenetrating polymer network(IPN) hydrogels. The factors that could influence swelling properties of 2-H-3-B-P-HPCS/PEG IPN hydrogels were studied, such as concentration of 2-H-3-B-P-HPCS, reaction temperature， amount of PEG and glutaral. The 2-H-3-B-P-HPCS/PEG IPN hydrogels were investigated by SEM and IR. Aciclovir as a model drug was used to study the release performance. The results show that 2-H-3-B-P-HPCS/PEG IPN hydrogels have good swelling property, pH sensibility and drug releasing ability and can be used for a new drug carrier.