首页 | 本学科首页   官方微博 | 高级检索  
     检索      

冷应激对铜预投大鼠血清铜锌代谢、SOD活性及GSH含量的影响
引用本文:吴步猛,陈锡文,金月玲,叶筱琴,金晓冬,王一龙,赵慧玲,李安乐,管敏强.冷应激对铜预投大鼠血清铜锌代谢、SOD活性及GSH含量的影响[J].广东微量元素科学,2005,12(4):18-22.
作者姓名:吴步猛  陈锡文  金月玲  叶筱琴  金晓冬  王一龙  赵慧玲  李安乐  管敏强
作者单位:1. 温州医学院实验动物中心,浙江,温州,325000
2. 温州医学院药学院
3. 温州医学院检验与公共卫生学院
基金项目:温州医学院校科研和教改项目
摘    要:为揭示应激对体内微量元素代谢的影响和机制,预先给予大鼠不同水平的铜3周后,采用冷束缚法使大鼠产生应激,测定了血清铜、锌水平及超氧化物歧化酶(SOD)活性、还原型谷胱甘肽(GSH)和丙二醛(MDA)含量。结果表明,高铜给予没有对清洁级大鼠生长产生明显的影响.血清铜、锌及铜锌比值变化不明显,但适量的铜给予能显著提高血清中SOD活性和GSH含量;冷应激处理后大鼠血清中Cu水平下降,Zn水平升高,同时SOD消耗降低,而GSH含量显著升高。表明冷应激可使大鼠体内铜锌代谢及SOD活性和GSH含量发生变化,适量的铜给予在应激状况下才发挥出积极的生理作用。

关 键 词:冷应激  大鼠:铜    超氧化物歧化酶(SOD)  还原型谷胱甘肽(GSH)
文章编号:1006-446X(2005)04-0018-05
修稿时间:2005年3月7日

Effects of Copper Pre-administration on Rat's Metabolism of Serum Copper and Zinc,Activity of SOD and the Content of GSH
WU Bu-meng,CHEN Xi-wen,JIN Yue-ling,et al.Effects of Copper Pre-administration on Rat''''s Metabolism of Serum Copper and Zinc,Activity of SOD and the Content of GSH[J].Trace Elements Science,2005,12(4):18-22.
Authors:WU Bu-meng  CHEN Xi-wen  JIN Yue-ling  
Institution:WU Bu-meng~1,CHEN Xi-wen~1,JIN Yue-ling~2,et al
Abstract:To reveal the effects and mechanism of stress on metabolism of trace element in vivo,80 SD rats of 28 days old were divided into 4 groups at random,mamely feeding water group,low coper group(LCu),moderate copper group(MCu),and high copper group(HCu),feeding the four groups with deionized water lower,mod,and higher dose of copper respectively by intragastric administration for 3 weeks.Every group was randomly divided into ambient temperature contrasting groups and cold stress groups. Then observe and analyze concentration of serum copper and serum zinc,activity of superoside dismutase(SOD),reduced glutathionc(GSH)and malondialdehyde(MDA)of every group.The results showed that higher copper administration had not marked effects on the growth of clear SD rats.Serum copper/zinc ratio was not significantly changed.However,appropriate copper administration overly elevated activity of SOD and level of GSH.Serum copper decreased and serum zinc increased after the rats were disposed with cold stress.At the same time,SOD was consumed and level of GSH was notably heightened.Thus these results indicated that cold stress can change rats' metabolism of copper and zinc,activity of SOD and level of GSH,and appropriate administration of copper may make positive physiological effects in stress state.
Keywords:cold stress  rat  copper  zinc  superoxide dismutase(SOD)  reduced glutathionc(GSH)
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号