乙肝疫苗注入后婴儿血液吞噬细胞吞噬功能变化的临床观察

为探讨乙开型肝炎表面抗原（ｈｅｐａｔｉｔｉｓ Ｂ ｓｕｒｆａｃｅ ａｎｔｉｇｅｎ，ＨＢｓＡｇ）阳性母亲的婴儿乙肝疫苗注入后早期机体免疫反应的特点，采用化我法测定了吞噬细胞的吞噬功能；用双抗原夹心法测定了抗－ＨＢｓ抗体。结果表明，（１）乙肝疫苗注入前两组间吞噬细胞的吞噬功能无明显差异，疫苗注入后３个月和６个月时实组外周血吞噬细胞的吞噬功能明显下降（Ｐ〈０．０５）。两组间同时间点相比，１个月和３个月都

Clinical Observation of Cellular Phagocytosis after Hepatitis B Vaccination in Infant

The characters of early immune response on the infants whose mothers with hepatitis B surface antigen (HBsAg) after hepatitis B vaccination were studied. The cellular phagocytosis was examined by luminolenhanced chemiluminescence assay, and the anti-HBs was examined by the double antigen sandwich technique. The results showed that (1) The cellular phagocytosis showed no significant difference between the two groups before hepatitis B vaccination, and after hepatitis B vaccination it decreased obviously in 3rd and 6th month in infants born to mothers with HBaAg (P <0.05). In 1st and 3rd month there was significant difference between the two groups (P <0.01, P<0.05). (2) The ant-HBs positive rate in infant born to mothers with HBsAg did not differ from that of the controls significantly in the same time after hepatitis B vaccination. The characters of early immune response to hepatitis B vaccine are different between the infants born to mothers with HBsAg and those born bo health mothers, and the infants of two groups represented defferential law in cellular phagocytosis.