舒芬太尼不同浓度对气管插管全麻患者插管反应的抑制效果比较

目的比较舒芬太尼不同靶控浓度对气管插管全麻患者插管反应的抑制效果。方法抽取清远市中医院2014年7月—2015年6月78例气管插管全麻患者,根据舒芬太尼血浆靶控浓度将该78例患者分为低质量浓度组(0.4 ng/m L)和高质量浓度组(0.6 ng/m L),两组各39例。比较两组麻醉诱导前(T1)、气管插管时(T2)、插管后1 min(T3)、插管后3 min(T4)和插管后5 min(T5)的平均动脉压(MAP)、心率(HR)指标。结果低质量浓度组患者血压心率较为平稳,各时点MAP、HR相比较差异无统计学意义(P0.05);高质量浓度组患者血压心率变化幅度较大,T3、T4时点MAP、HR较T1、T2、T3均明显较低,差异具有统计学意义(P0.05);低质量浓度组T3、T4时点MAP、HR较高浓度组明显较高,具有统计学意义(P0.05)。结论不同浓度舒芬太尼对行气管插管全麻患者的插管反应抑制效果不同,质量浓度维持在0.4 ng/m L具有较好的稳定血压心率作用,有利于达到理想的插管反应抑制效果。

Compare the Inhibitory Effect of Different Concentration of Sufentanil in Patients with Tracheal Intubation Under General Anesthesia

Objective Compare the inhibition effect of different concentration of sufentanil in patients with tracheal intubation under general anesthesia. Methods Choose 78 cases of patients with tracheal intubation anesthesia between 2014 July and 2015 June, the 78 cases were divided into low concentration group (0. 4 ng/mL) and high concentration group (0. 6 ng/mL) according to the target concentration of sufentanil plasma, 39 cases in each group. Compare the mean arterial pressure ( MAP) and heart rate (HR) in the time of before anesthesia induction (T1), tracheal Intubation (T2), 1min after intubation ( T3 ) , 3 min after intubation ( T4 ) and 5 min after intubation ( T5 ) . Results The blood pressure and heart rate of low concentration group were stable, MAP and HR have no statistically significant ( P >0. 05 );The blood pressure heart rate of high concentration group has a great changes, the MAP and HR of T3, T4 time point were significantly lower than T3, T4 time point, the difference was statistically significant ( P<0. 05 ); The MAP and HR of low concentration group at T3 and T4 time point were significantly higher than the high concentration group, has statistical significance ( P < 0. 05 ) . Conclusion The inhibitory effect of different concentration of sufentanil on intubation response in patients with tracheal intubation anesthesia is different, the concentration of 0. 4 ng/mL has good stable blood pressure and heart rate, advantageous to achieve ideal effect of intubation response inhibition.