| 低剂量铅对大鼠脑组织一氧化氮合酶表达及活性的影响 |
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| 引用本文： | 宋丽华,张亨山.低剂量铅对大鼠脑组织一氧化氮合酶表达及活性的影响[J].广东微量元素科学,1998,5(4):21-24. |
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| 作者姓名： | 宋丽华 张亨山 |
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| 作者单位： | 中国预防医学科学院环境卫生监测所!北京，100021，中国预防医学科学院环境卫生监测所!北京，100021，中国预防医学科学院环境卫生监测所!北京，100021，中国预防医学科学院环境卫生监测所!北京，100021，中国预防医学科学院环境卫生监测所!北京，100021 |
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| 摘 要： | 为探讨低水平铅损伤记忆功能的作用机理，采用ＮＡＤＰＨ－黄递酶组织化学方法和＾３Ｈ－瓜氨酸生成生物检测技术，观察了新生大鼠在４００ｍｇ／Ｌ醋酸铅染毒４０天后对脑组织内一氧化氮合酶表达及活性的影响。结果显示大脑皮质一氧化氮合酶阳性神经元数量明显减少（Ｐ〈０．０５），在海马区脑组织内一氧化氮合酶活性降低５４．４％。结论：低水平铅暴露后可抑制大鼠脑组织内一氧化氮合酶的表达及活性。
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| 关 键 词： | 铅 一氧化氮合酶 脑组织 活性 脑损伤 |
Effect of Low Level Lead on Expression and Activity of Nitric Oxide Synthase in Rat Brain |
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| Song Lihua, Zhang hengshan, Zhao Xilong,Guo Runrong, Qin Yuhui.Effect of Low Level Lead on Expression and Activity of Nitric Oxide Synthase in Rat Brain[J].Trace Elements Science,1998,5(4):21-24. |
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| Authors: | Song Lihua Zhang hengshan Zhao Xilong Guo Runrong Qin Yuhui |
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| Abstract: | To inveshgate the mechanism of effect of lead on learning and memory, the activity and distribution of nitric oxide synthase in neonatal rat brain exposed to 400mg/L lead acetate for 40 days were observed by means of NADPH-diaphorase histochendstry and 3H-citrulline generation bioassay. The results showed that the number of nitric oxide synthase positive neumns in the cerebral cortex was significantly reduced (P < 0.05), and nitric oxide synthase achvity in the hippocampus was decreased by 54.4% compared to the control group. Conclusion: the expression and activity of nitric oxide synthase were suppressed remarkably in brain of rats after exposure to low level of lead. |
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| Keywords: | Lead Rat Nitric oxide Synthase |
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