| Fast electron transfer repair of oxidizing OH adduct of dGMP by chlorogenic acid |
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| 作者姓名： | 马建华 钱素平 林维真 姚思德 |
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| 作者单位： | Laboratory of Radiation Chemistry，Shanghai Institute of Nuclear Research，Chinese Academy of Sciences，Shanghai 201800，China |
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| 基金项目： | ProjectsupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .39130 0 5 0 ) |
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| 摘 要： | ＥｘｔｅｎｓｉｖｅｓｔｕｄｉｅｓｏｆｒａｄｉａｔｉｏｎｏｒｃｈｅｍｉｃａｌｉｎｊｕｒｙｏｆｂｉｏｌｏｇｉｃａｌｔａｒｇｅｔｍｏｌｅｃｕｌｅｓｄｅｍｏｎｓｔｒａｔｅｔｈａｔＯＨｒａｄｉｃａｌ,ｔｈｅｍｏｓｔｒｅａｃｔｉｖｅｏｘｙｇｅｎｓｐｅｃｉｅｓ,ｒｅａｃｔｓｗｉｔｈｂｉｏｌｏｇｉｃａｌｍａｃｒｏｍｏｌｅｃｕｌｅｓ,ｓｕｃｈａｓＤＮＡ,ｉｎｄｕｃｉｎｇｂａｓｅａｌｔｅｒａｔｉｏｎｓ,ｂａｓｉｃｓｉｔｅｓ,ａｎｄｓｔｒａｎｄｂｒｅａｋｓ,ｒｅｓｕｌｔｅｄｉｎｖａｒｉｏｕｓｐａｔｈｏｇｅｎｅｓｉｓ,ｓｕｃｈ…
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| 关 键 词： | pulse radiolysis chlorogenic acid 2′\|deoxyguanosine\|5′\|monophosphate. |
| 收稿时间： | 14 March 1998 |
Fast electron transfer repair of oxidizing OH adduct of dGMP by chlorogenic acid |
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| Jianhua Ma,Suping Qian,Weizhen Lin,Side Yao.Fast electron transfer repair of oxidizing OH adduct of dGMP by chlorogenic acid[J].Science in China(Chemistry),1998,41(5):556-560. |
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| Authors: | Jianhua Ma Suping Qian Weizhen Lin Side Yao |
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| Institution: | (1) Laboratory of Radiation Chemistry, Shanghai Institute of Nuclear Research, Chinese Academy of Sciences, 201800 Shanghai, China |
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| Abstract: | Pulse radiolysis of chlorogenic acid (CGA) as well as CGA and 2′-deoxyguanosine-5′-monophosphate (dGMP) has been carried out
in aqueous solution using pulse radiolytic technique. From detailed kinetic analyses, the kinetic parameters have been obtained.
Accordingly, the reaction mechanisms are suggested. Previous studies have indicated that CGA can either scavenge OH radical
or repair oxidizing OH radical adduct of dGMP effectively.
Project supported by the National Natural Science Foundation of China (Grant No. 39130050) |
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| Keywords: | pulse radiolysis chlorogenic acid 2′ -deoxyguanosine-5′ -monophosphate |
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