| Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT)——Preparation,characterization and anticancer activities of an amphiphilic phthalocyanine ZnPcS_2P_2 |
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| 引用本文： | 黄金陵
,陈耐生
,黄剑东
,刘尔生
,薛金萍
,杨素苓
,黄自强
,孙建成.Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT)——Preparation,characterization and anticancer activities of an amphiphilic phthalocyanine ZnPcS_2P_2[J].中国科学B辑(英文版),2001,44(2). |
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| 作者姓名： | 黄金陵 陈耐生 黄剑东 刘尔生 薛金萍 杨素苓 黄自强 孙建成 |
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| 作者单位： | HUANG Jinling CHEN NaishengHUANG Jiandong LIU Ersheng XUE JinpingYANG Suling HUANG Ziqiang SUN JianchengInstitute of Research on Functional Materials，Department of Chemistry，Fuzhou University，Fuzhou 350002，China;Pharmacology Research Section，Fujian Medical University，Fuzhou 350004，China |
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| 基金项目： | the Ministry of Science and Technology of China (Grant No. 96-901-01-67) and the National Natural Science Foundation of China (Grant No. 29871108). |
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| 摘 要： | A series of sulfonated (S) phthalimidomethyl (P) zinc phthalocyanines (Pc) was synthesized in a reaction, in which both kinds of substituents were introduced to ZnPc simultaneously. The products were separated by HPLC. The five different fractions obtained were further purified by a membrane separation method, and then characterized by UV/Vis, IR, element analysis and the abilities to generate singlet oxygen upon irradiation by light as well as a preliminary determination of in vitro antitumor activities. The results show that one of the five separating parts with formula of ZnPcS2P2 exhibited rather good PDT activity. The compound was further characterized by NMR, MS and thermal analysis. Studies on in vivo antitumor activities of ZnPcS2P2 as photosensi-tizer show that its inhibitory rate was up to 89.8% and 90.8% for S180 and U14 solid tumors transplanted in mice respectively when the dosage of drug was 2 mg/kg and the dosage of laser light with 670 nm wavelength was 72 J/cm2. Several structural factor
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Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT)--Preparation, characterization and anticancer activities of an amphiphilic phthalocyanineZnPcS_2P_2 |
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| Huang Jinling,CHEN Naisheng,Huang Jiandong,LIU Ersheng,XUE Jinping,YANG Suling,HUANG Ziqiang,SUN Jiancheng.Metal phthalocyanine as photosensitizer for photodynamic therapy (PDT)--Preparation, characterization and anticancer activities of an amphiphilic phthalocyanineZnPcS_2P_2[J].Science in China(Chemistry),2001,44(2). |
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| Authors: | Huang Jinling CHEN Naisheng Huang Jiandong LIU Ersheng XUE Jinping YANG Suling HUANG Ziqiang SUN Jiancheng |
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| Institution: | 1. Institute of Research on Functional Materials, Department of Chemistry, Fuzhou University,
2. Pharmacology Research Section, Fujian Medical University, |
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| Abstract: | A series of sulfonated (S) phthalimidomethyl (P) zinc phthalocyanines (Pc) was synthesized in a reaction, in which both kinds of substituents were introduced to ZnPc simultaneously. The products were separated by HPLC. The five different fractions obtained were further purified by a membrane separation method, and then characterized by UV/Vis, IR, element analysis and the abilities to generate singlet oxygen upon irradiation by light as well as a preliminary determination of in vitro antitumor activities. The results show that one of the five separating parts with formula of ZnPcS2P2 exhibited rather good PDT activity. The compound was further characterized by NMR, MS and thermal analysis. Studies on in vivo antitumor activities of ZnPcS2P2 as photosensi-tizer show that its inhibitory rate was up to 89.8% and 90.8% for S180 and U14 solid tumors transplanted in mice respectively when the dosage of drug was 2 mg/kg and the dosage of laser light with 670 nm wavelength was 72 J/cm2. Several structural factors influenced on the PDT activities were discussed. |
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| Keywords: | metal phthalocyanine photodynamic therapy amphiphilicity anticancer photosensitizer |
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