Investigations on the adsorbents for uremic middle molecular toxins (II) |
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Authors: | Hong Wang Zhi Yuan Xiaohang Liu Xinlian Teng and Binglin He |
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Institution: | (1) State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry Nankai University, 300071 Tianjin, China |
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Abstract: | Chitosan resins, which clinically served as adsorbents in hemo perfusion therapy, were prepared with reversed-phase suspension
methodology using three differently structured crosslinking agents, methanal, glyoxal and glutaraldehyde. And the glyoxal
and glutaraldehyde crosslinked chitosan resins were reduced with NaBH4 afterwards. By analyzing the results from FTIR and SEM, it was found that the reduction treatment to the adsorbents efficiently
improved the chemical stability of these chitosan resins, and the shifts in crosslinking agents exerted influences over the
morphologies of the adsorbents obviously. After being put to use in the adsorption tests upon some model uremic middle molecular
toxins and BSA in vitro, all three adsorbents demonstrated a fairly realistic adsorption capability to the model toxins but
little to BSA. And the adsorption process reached the equilibrium in a clinically qualified short time. But the adsorption
capacities of these adsorbents to the model toxins were quite different. It had been found that with the growing of fatty
chain length of crosslinking agent, these adsorbents showed a gradually increased adsorption capacity to the model toxins,
and the glutaraldehyde crosslinked chitosan resin behaved best. |
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Keywords: | hemoperfusion uremia middle molecular toxins adsorbent crosslinked chitosan |
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