| Polymeric adsorbents with peptide pendants as artificial receptors for β-Mactam antibiotics by mimicking the binding sites of β-lactamases |
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| 引用本文： | 马建标,谢志东,王永健,王亦农,范云鸽,何炳林.Polymeric adsorbents with peptide pendants as artificial receptors for β-Mactam antibiotics by mimicking the binding sites of β-lactamases[J].中国科学B辑(英文版),1997(4). |
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| 作者姓名： | 马建标 谢志东 王永健 王亦农 范云鸽 何炳林 |
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| 作者单位： | State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China，State Key Laboratory of Functional Polymer Materials for Adsorption and Separation，Institute of Polymer Chemistry，Nankai University，Tianjin 300071，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (No. 59493207) |
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| 摘 要： | A scries of polymeric adsorbents with peptide pendants were designed as the artificial receptors of β-laetarn antibiotics by mimicking the structures of binding site in β-lactamases.Crosslinked poly(N,N-dimethyl acry-lamide) gel as a carrier was prepared by suspension copolyrnerization of N,N-dimethyl acrylamide and N,N-bisacryl-diaminoethane and then functionalized with ethylenediamine after partial hydrolysis.Using solid-phase peptide synthesis with symmetrical anhydride of protected amino acid step by step,various peptide pendants were respectively anchored onto the functionalized carrier.The adsorption properties of these peptide-containing adsorbents for β-lactam antibiotics such as ampicillin and cefotaxime were then studied.The results showed that only those adsorbents in which peptide chains contained more than one lysine residues could obviously adsorb both β-lactams and that static interaction as well as hydrogen bond played an important role during the adsorption
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