| STUDIES ON BRADYKININ POTENTIATING PEPTIDE (BPP) FROM VENOM OF ZHEJIANG PIT VIPER (Agkistrodon halys pallas)——RELATIONSHIP BETWEEN STRUCTURE AND FUNCTION OF BPP_1 |
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| 引用本文： | 王茂音,罗珊珊,戚正武.STUDIES ON BRADYKININ POTENTIATING PEPTIDE (BPP) FROM VENOM OF ZHEJIANG PIT VIPER (Agkistrodon halys pallas)——RELATIONSHIP BETWEEN STRUCTURE AND FUNCTION OF BPP_1[J].中国科学B辑(英文版),1983(7). |
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| 作者姓名： | 王茂音 罗珊珊 戚正武 |
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| 作者单位： | Biochemistry Department of Anhui Medieal College，Shanghai Institute of Biochemistry，Academia Sinica，Shanghai Institute of Biochemistry，Academia Sinica |
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| 摘 要： | 1 The structure of the bradykinin potentiating peptide component BPP_1 from a 70% methanol extract of the lyophilyzed powder of pit viper from Zhejiang Province is shown as follows: Glu·Gly·Arg·Pro·Pro·Gly·Pro·Pro·Ile·Pro·Pro2 When the pyroglutamyl residue was removed by pyroglutamate aminopeptidase, the activity of BPP_1 was enhanced two-fold but decreased gradually during the course of Edman degradation. The above facts show that the structure integrity of the C-terminal is absolutely necessary for the activity of BPP_1.
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