| A new synthesis of A-nor-△~(3(5),9(10)) estradiene-2,17-dione |
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| 引用本文： | 周向东,周维善,王钟麒.A new synthesis of A-nor-△~(3(5),9(10)) estradiene-2,17-dione[J].中国科学B辑(英文版),1997(3). |
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| 作者姓名： | 周向东 周维善 王钟麒 |
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| 作者单位： | Shanghai Institute of Organic Chemistry，Chinese Academy of Science's，Shanghai 200032，ChinaDepartment of Chemistry，Faculty of Preclinical Science，the Third Military Medical University，Chongqing 630038，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Science's，Shanghai 200032，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Science's，Shanghai 200032，China National Laboratory of Contraceptives and Devices Research，Shanghai Institute of Planned Parenthood Research，Shanghai，200032，China |
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| 基金项目： | Project supported by the National Committee for Planned Parenthood，National Laboratory of Contraceptives，Devices Research，Shanghai Institute of Planned Parenthood Research |
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| 摘 要： | A-nor-Δ3(5),9(10)-estradiene-2,17-dione 1,a potential precursor for synthesis of some new steroidalcontraceptives,was synthesized from 3β-hydroxy-5α-chloro-6β,19-epoxy-androstane-17-one 6 as the sterting mater al,which is the key intermediate of steroidal contraceptive of norethindrone,in an overall yield of 25% in 5 steps through the sequence of 5 reactions:(i) oxidative dccyclization,(ii) decarhoxylative cyclization,(iii) reductive decy clization,(iv) dehydroxy methylation,(v) deacetoxylation
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| 关 键 词： | △~(3(5) 9(10))-estradiene-2 17-dione oxidative decyclization decarboxylative cyclization deacetoxylation |
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