首页 | 本学科首页   官方微博 | 高级检索  
     检索      

Theoretical studies on intratriplex DNA with 5-bromocytosine
作者姓名:杨林静  刘峁子  李清  王琛  白春礼
作者单位:Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080,China
基金项目:ProjectsupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .2 95 2 30 4)andtheFoundationoftheChi neseAcademyofSciences
摘    要:OligonucleotidecanrecognizethemajorgrooveofdoublehelicalDNAatspecificsequencesbyformingHoogsteenorreverseHoogsteenhydrogenbondswithpurinebasesoftheWatsonCrickbasepairs,resultinginatriplehelix1].Triplehelixformingoligonucleotidescanbeusedtoselectivelyc…

收稿时间:9 April 1998

Theoretical studies on intratriplex DNA with 5-bromocytosine
Linjing Yang,Maozi Liu,Qing Li,Chen Wang,Chunli Bai.Theoretical studies on intratriplex DNA with 5-bromocytosine[J].Science in China(Chemistry),1998,41(6):646-651.
Authors:Linjing Yang  Maozi Liu  Qing Li  Chen Wang  Chunli Bai
Institution:(1) Institute of Chemistry, Chinese Academy of Sciences, 100080 Beijing, China
Abstract:The relative stability of three intratriplex DNAs with substitution of 5-bromocytosines for cytosines in different strands and the corresponding unsubstituted intratriplex have been respectively investigated by molecular mechanics calculation. The results showed that intratriplex YTC with substitution occurring in strand III is the most stable and YTCY with substitution occurring in both strand I and III is the most unstable. Sugar conformations of the four intratriplexes are mainly C3’-endo. However, there are more C2’-endo sugar conformations in YTCY than in other intratriplexes, especially in strand I and III. Thus intratriplex YTCY is the combination of A-DNA and B-DNA, the other three intratriplexes are classical A-type DNA. Project supported by the National Natural Science Foundation of China (Grant No. 2952304) and the Foundation of the Chinese Academy of Sciences.
Keywords:bromocytosine  intratriplex DNA  molecular mechanics  
本文献已被 CNKI SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号