Stereochemical assignments of 22-isoxazolinylsteroids using circular dichroism

Circular dichroism (CD) spectra of 22-hydroxy- and 22-acetoxy-22-isoxazolinylsteroids were studied. The configuration of the C-5′ center of the heterocycle was established from the sign of the n-π*-transition band of the azomethine chromophore. The band molecular ellipticity was shown to depend on the mutual placement of the isoxazoline ring and the steroid skeleton of the studied compounds. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 495–499, September-October, 2008.