超分子化学药物研究

超分子药物化学是超分子化学在药学领域的新发展．该领域研究活跃，发展迅速，是一个充满活力的新兴交叉学科领域，并正在逐渐变成一个相对独立的研究领域．迄今已有许多两个或两个以上分子通过非共价键力形成的超分子化学药物应用于临床．超分子化学药物可具有良好的安全性、低毒性、不良反应少、高生物利用度、药物靶向性强、多药耐药性小、生物相容性好、高疗效以及其开发成本低、周期短、成功可能性大等诸多优点而备受关注，显示出超分子化学药物具有很大的发展潜力．本文首次给出了超分子药物的定义．结合自己的工作，参考国内外文献综述了超分子化学药物在抗肿瘤、抗炎镇痛、抗疟、抗菌、抗真菌、抗结核、抗病毒、抗癫痫、作为心血管和磁共振成像药物等医药领域的研究与开发状况，并展望其发展趋势与应用前景．

Research in supramolecular chemical drugs

The supramolecular medicinal chemistry is a new extension of supramolecular chemistry in pharmaceuti-cal sciences, and this research field has been a quite rapidly developing, increasingly active, and newly rising high-light interdiscipline, and is gradually becoming a relatively independent area of research. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through noncovalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in cl...