| 荧光光谱法研究注射用头孢美唑钠与牛血清白蛋白的相互作用 |
| |
| 引用本文： | 张怀斌,李怀祥,马丽英,刘雪.荧光光谱法研究注射用头孢美唑钠与牛血清白蛋白的相互作用[J].分析科学学报,2011,27(3):321-325. |
| |
| 作者姓名： | 张怀斌 李怀祥 马丽英 刘雪 |
| |
| 作者单位： | 滨州医学院化学教研室;山东师范大学化学化工与材料科学学院; |
| |
| 基金项目： | 国家自然科学基金(No.60671010); 滨州医学院科研专项资助项目(BY2009KJ30) |
| |
| 摘 要： | 运用荧光光谱法研究了注射用头孢美唑钠(Cefmetazole Sodium,CS)与牛血清白蛋白(BSA)的相互作用.CS对BSA具有荧光猝灭作用,其猝灭方式为静态猝灭,求出了猝灭常数,结合常数及结合位点数.在297 K和311 K时用Stern-Volmer方程和热力学方程处理实验数据,得到了结合常数KA、热力学参数...
|
| 关 键 词： | 头孢美唑钠 牛血清白蛋白 荧光光谱 热力学参数 Zn2+ Cu2+ |
Study on the Interaction between Cefmetazole Sodium for Injection and Bovine Serum Albumin by Fluorescence Spectroscopy |
| |
| ZHANG Huai-bin,LI Huai-xiang,MA Li-ying,LIU Xue.Study on the Interaction between Cefmetazole Sodium for Injection and Bovine Serum Albumin by Fluorescence Spectroscopy[J].Journal of Analytical Science,2011,27(3):321-325. |
| |
| Authors: | ZHANG Huai-bin LI Huai-xiang MA Li-ying LIU Xue |
| |
| Institution: | ZHANG Huai-bin*1,LI Huai-xiang2,MA Li-ying1,LIU Xue1(1.Chemistry Staff Room,Binzhou Medical College,Yaitai 264003,2.College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014) |
| |
| Abstract: | The interaction between cefmetazole sodium for injection and bovine serum albumin(BSA) was studied by the fluorescence spectroscopy.The fluorescence of BSA was quenched by cefmetazole sodium for injection,and the combination was a static quenching process.The quenching data were analyzed according to Stern-Volmer equation,and the quenching constant,binding constant,binding sites and thermodynamic parameters were obtained.Furthermore,the interaction between cefmetazole sodium for injection and BSA was invest... |
| |
| Keywords: | Cefmetazole sodium Bovine serum albumin Fluorescence spectroscopy Thermodynamic parameter Zinc ions Copper ions |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
