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| 十二烷基磺基甜菜碱与铂电极支撑的磷脂双层膜作用的电化学研究 | |
| 引用本文： | 高鹏,张渝阳,马勇,刘娜,刘静,于旦旦,臧树良.十二烷基磺基甜菜碱与铂电极支撑的磷脂双层膜作用的电化学研究[J].分析科学学报,2010,26(4). |
| 作者姓名： | 高鹏 张渝阳 马勇 刘娜 刘静 于旦旦 臧树良 |
| 作者单位： | 1. 辽宁大学化学学院,辽宁沈阳,110036;中油长城钻探工程有限公司钻井液公司,北京,100101 2. 辽宁大学化学学院,辽宁沈阳,110036 3. 辽宁大学化学学院,辽宁沈阳,110036;辽宁石油化工大学,辽宁抚顺,113001 |
| 摘 要： | 以铂电极支撑的磷脂双层膜(Supported Bilayer Lipid Membrane,s-BLM)作为生物膜的模型,以Fe(CN)36-和Fe(CN)64-为探针分子,利用循环伏安法(CV)和交流阻抗谱(EIS)研究两性表面活性剂十二烷基磺基甜菜碱(Dodecyl Sulfobetaine,DSB)对s-BLM相互作用。结果显示,DSB可以嵌入到s-BLM的疏水区,容易使其表面分子的排列发生变化,产生缺陷或孔洞,探针分子Fe(CN)63-和Fe(CN)64-可以通过这些微孔接近电极,产生氧化还原响应。并且作用时间、DSB的浓度以及胆固醇的存在与否对二者的相互作用有直接影响。此外作用后的双层膜在0.1mol/LKCl溶液中能够自我修复,这表明DSB与s-BLM的相互作用是可逆的。 |
| 关 键 词： | 支撑磷脂双层膜 循环伏安法 交流阻抗法 表面活性剂 |
Electrochemical Study on the Interaction of Dodecyl Sulfobetaine with a Supported Lipid Bilayer Membrane |
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| GAO Peng,ZHANG Yu-yang,MA Yong,LIU Na,LIU Jing,YU Dan-dan,ZANG Shu-liang.Electrochemical Study on the Interaction of Dodecyl Sulfobetaine with a Supported Lipid Bilayer Membrane[J].Journal of Analytical Science,2010,26(4). | |
| Authors: | GAO Peng ZHANG Yu-yang MA Yong LIU Na LIU Jing YU Dan-dan ZANG Shu-liang |
| Institution: | GAO Peng1,2,ZHANG Yu-yang1,LIU Na1,LIU Jing1,YU Dan-dan1,ZANG Shu-liang1,3(1.College of Chemistry,Liaoning University,Shenyang 110036,2.Great Wall Drilling Engineering Company PetroChina,Beijing 100101,3.Liaoning Petrochemical Engineering University,Fushun 113001) |
| Abstract: | With supported bilayer lipid membrane (s-BLM) serving as a biomembrane model,and Fe(CN)3-6 and Fe(CN)4-6 serving as redox probes,the influence of dodecyl sulfobetaine(DSB) on s-BLMs was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The following conclusions were obtained. There are some interactions between DSB and s-BLM,and DSB can be inserted into the hydrophobic areas of bilayer lipid membrane and decrease the orderliness of lecithin molecule arrangement and in... |
| Keywords: | Supported lipid bilayer membrane Cyclic voltammetry Electrochemical impedance spectroscopy Surfactants |
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