| 多柔比星稀土配合物与人血清白蛋白相互作用的研究 |
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| 引用本文： | 赵龙,卢继新,项振玲,李娟,徐靖源.多柔比星稀土配合物与人血清白蛋白相互作用的研究[J].分析科学学报,2011,27(5):581-585. |
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| 作者姓名： | 赵龙 卢继新 项振玲 李娟 徐靖源 |
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| 作者单位： | 天津医科大学药学院,天津,300070 |
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| 基金项目： | 国家自然科学基金(N0.20971099) |
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| 摘 要： | 运用荧光光谱法研究了多柔比星稀土配合物(ADM-M)与人血清白蛋白(HSA)的相互作用.结果表明:多柔比星稀土配合物对HSA的荧光有较强的猝灭作用,其荧光猝灭为混合猝灭过程.求得多柔比星稀土配合物与HSA的结合常数、结合位点数.由热力学参数确定了多柔比星稀土配合物与HSA的作用力类型.同时用同步荧光光谱法考察了多柔比星...
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| 关 键 词： | 多柔比星 稀土金属离子配合物 人血清白蛋白 荧光光谱 |
Study on the Interaction of Adriamycin Rare Earth Complexes with Human Serum Albumin |
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| ZHAO Long,LU Ji-xin,XIANG Zhen-ling,LI Juan,XU Jing-yuan.Study on the Interaction of Adriamycin Rare Earth Complexes with Human Serum Albumin[J].Journal of Analytical Science,2011,27(5):581-585. |
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| Authors: | ZHAO Long LU Ji-xin XIANG Zhen-ling LI Juan XU Jing-yuan |
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| Institution: | ZHAO Long,LU Ji-xin*,XIANG Zhen-ling,LI Juan,XU Jing-yuan (Department of Pharmacy,Tianjin Medical University,Tianjin 300070) |
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| Abstract: | The interaction of adriamycin rare earth complexes(ADM-M) with human serum albumin(HSA) have been studied by fluorescence spectrum.The results showed that ADM-M strongly quenched the fluorescence produced by HSA and this quenching could be interpreted in terms of mixture quenching.The binding constants and the number of binding sites between them have been measured.Based on the thermodynamic parameter analysis,the main binding force between them was confirmed.Meanwhile,the effect of ADM-M on the conformatio... |
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| Keywords: | Adriamycin Rare earth metal complexes Human serum albumin Fluorescence spectrum |
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