|
|||||
|
|
| 尼卡地平分子聚合物的制备及识别性能研究 | |
| 引用本文： | 苏红慧,冯丽霞,苏会玲,修荣.尼卡地平分子聚合物的制备及识别性能研究[J].分析科学学报,2012,28(1):71-74. |
| 作者姓名： | 苏红慧 冯丽霞 苏会玲 修荣 |
| 作者单位： | 1. 河北省任丘市华北石油总医院药材科,河北任丘,062552 2. 河北医科大学外语部,河北石家庄,050017 3. 河北省任丘市华北石油总医院肿瘤血液内科,河北任丘,062552 4. 河北医科大学药学院,河北石家庄,050017 |
| 摘 要： | 采用分子印迹技术合成了以尼卡地平为模板分子,甲基丙烯酸为功能单体的分子印迹聚合物(MIP).运用平衡结合实验研究了聚合物的吸附特性和选择识别能力.通过Scatchard方程分析,结合位点的离解常数Kd=1.03 mmol·L-1,最大表观结合常数Qmax=18.76 μmol·g-1.结果表明,分子印迹聚合物对尼卡地平呈现出较高的吸附性和选择识别性,对尼卡地平药物的分离富集和检测具有实际临床意义. |
| 关 键 词： | 尼卡地平 分子印迹聚合物 分子识别 |
Study on Preparation and Recognition Characteristics of Nicardipine Molecularly Imprinted Polymer |
|
| SU Hong-hui , FENG Li-xia , SU Hui-ling , XIU Rong.Study on Preparation and Recognition Characteristics of Nicardipine Molecularly Imprinted Polymer[J].Journal of Analytical Science,2012,28(1):71-74. | |
| Authors: | SU Hong-hui FENG Li-xia SU Hui-ling XIU Rong |
| Institution: | 1.Department of Medical Material,General Hospital of Huabei Oil Field Company,Renqiu 062552; 2.Department of Foreign Language,Hebei Medical Univercity,Shijiazhuang 050017; 3.Department of Tumor and Blood,General Hospital of Huabei Oil Field Company,Renqiu 062552; 4.Institute of Pharmacy,Hebei Medical Univercity,Shijiazhuang 050017) |
| Abstract: | With nicardipine as template molecule,methacrylic acid as function monomer,a molecularly imprinted polymer(MIP) was prepared by the molecular imprinting technique.The MIP was investigated in equilibrium binding experiment to evaluate its adsorption property and selective recognition.Scatchard analysis showed that the dissociation constant(Kd) was 1.03 mmol/L and the apparent maximum binding capacity(Qmax) was 18.76 μmol/g.It indicated that the MIP had high selectivity and high recognition ability for nicardipine. |
| Keywords: | Nicardipine Molecular imprinted polymer Molecular recognition |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |