| 紫外分光光度法测定抗癌药物来曲唑的含量 |
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| 引用本文： | 郑静,徐菁利,唐伯合金,陈燕青,赵家昌,吴昊,鲁昊.紫外分光光度法测定抗癌药物来曲唑的含量[J].分析科学学报,2010,26(1). |
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| 作者姓名： | 郑静 徐菁利 唐伯合金 陈燕青 赵家昌 吴昊 鲁昊 |
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| 作者单位： | 上海工程技术大学化学化工学院,上海,201620 |
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| 基金项目： | 上海市教委科研创新项目(No.09YZ374) |
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| 摘 要： | 建立了紫外分光光度法测定药物来曲唑含量的方法。在乙腈溶液中,来曲唑的最大吸收波长在240 nm处,摩尔吸收系数为3.396×104L.mol-1.cm-1,来曲唑的浓度在2.89×10-6~2.31×10-5mol/L范围内吸光度与浓度呈良好的线性关系。该方法操作简单,重现性好,准确,用于来曲唑片剂含量的测定,结果满意。
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| 关 键 词： | 来曲唑 紫外分光光度法 测定 |
Determination of the Anti-cancer Drug of Letrozole by UV Spectrophotometry |
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| ZHENG Jing,XU Jing-li,TANG Bo-hejin,CHEN Yan-qing,ZHAO Jia-chang,WU Hao,LU Hao.Determination of the Anti-cancer Drug of Letrozole by UV Spectrophotometry[J].Journal of Analytical Science,2010,26(1). |
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| Authors: | ZHENG Jing XU Jing-li TANG Bo-hejin CHEN Yan-qing ZHAO Jia-chang WU Hao LU Hao |
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| Institution: | College of Chemistry and Chemical Engineering;Shanghai University ofEngineering Science;Shanghai 201620 |
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| Abstract: | A new method for the determination of letrozole by UV spectrophotometry was developed. Using acetonitrile as solvent and 240 nm measuring wavelength, the absorbance is proportional to the concentration of letrozole in the range of 2.888×10~(-6)～2.310×10~(-5) mol/L. The method was quite simple, reproducible, accurate and reliable. It is applicable to the determination of the content of letrozole in tablet. |
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| Keywords: | UV spectrophotometry Letrozole Determination |
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