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| 5-氟尿嘧啶-1-乙酸合铜(Ⅱ)的合成及其与DNA的作用 | |
| 引用本文： | 王志平,张强,宋玉民,黄键,王流芳.5-氟尿嘧啶-1-乙酸合铜(Ⅱ)的合成及其与DNA的作用[J].无机化学学报,2005,21(9):1397-1401. |
| 作者姓名： | 王志平 张强 宋玉民 黄键 王流芳 |
| 作者单位： | 1. 兰州大学第二医院泌尿外科研究所,兰州,730000 2. 西北师范大学化学化工学院,兰州,730070 3. 兰州大学功能有机分子化学国家重点实验室,兰州,730000 |
| 基金项目： | 国家自然科学基金项目(No.50272027)资助，甘肃省高分子材料重点实验室和西北师范大学A级学科资助 |
| 摘 要： | The 5-fluorouracil-1-acetic acid (5FuAA) and its Cu(Ⅱ) complex (5FuAACu) were synthesized and the date for the crystal complex was obtained. The interaction of 5-fluorouracil-1-acetic acid (5FuAA) and its Cu(Ⅱ) complex (5FuAACu) with DNA was also investigated by using spectral, viscometric, electrochemical and agarose gel electrophoresis methods. The results of interaction with DNA suggest that both 5FuAA and 5FuAACu can bind to DNA in a static electricity attraction mode. But the attraction of 5FuAACu is greater than that of 5FuAA. |
| 关 键 词： | 5-氟尿嘧啶-1-乙酸合铜(Ⅱ) DNA 静电吸附 |
| 文章编号： | 1001-4861(2005)09-1397-05 |
| 收稿时间： | 2005-02-22 |
| 修稿时间： | 5/9/2005 12:00:00 AM |
The Interactions between 5-fluorouracil-1-acetic Acid and its Capper(Ⅱ) Complex with DNA |
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| WANG Zhi-Ping,ZHANG Qiang,SONG Yu-Min,HUANG Jiang and WANG Liu-Fang.The Interactions between 5-fluorouracil-1-acetic Acid and its Capper(Ⅱ) Complex with DNA[J].Chinese Journal of Inorganic Chemistry,2005,21(9):1397-1401. | |
| Authors: | WANG Zhi-Ping ZHANG Qiang SONG Yu-Min HUANG Jiang and WANG Liu-Fang |
| Institution: | Institute of Urology, Second Hospital of Lanzhou University, Lanzhou 730000,Institute of Urology, Second Hospital of Lanzhou University, Lanzhou 730000,College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070,State Key Laboratory of Functional Organic Chemistry, Lanzhou University, Lanzhou 730000 and State Key Laboratory of Functional Organic Chemistry, Lanzhou University, Lanzhou 730000 |
| Abstract: | The 5-fluorouracil-1-acetic acid (5FuAA) and its Cu! complex (5FuAACu) were synthesized and the date for the crystal complex was obtained. The interaction of 5-fluorouracil-1-acetic acid (5FuAA) and its Cu! complex (5FuAACu) with DNA was also investigated by using spectral, viscometric, electrochemical and agarose gel electrophoresis methods. The results of interaction with DNA suggest that both 5FuAA and 5FuAACu can bind to DNA in a static electricity attraction mode. But the attraction of 5FuAACu is greater than that of 5FuAA. |
| Keywords: | 5FuAACu DNA static attraction |
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