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有机锡9-芴酮-4-甲酸酯的合成、结构及抗癌活性
引用本文:张复兴,邓欣,杨哲豪,张鑫,符康霞,盛良兵,朱小明,蒋伍玖,庾江喜.有机锡9-芴酮-4-甲酸酯的合成、结构及抗癌活性[J].无机化学学报,2023,39(7):1287-1294.
作者姓名:张复兴  邓欣  杨哲豪  张鑫  符康霞  盛良兵  朱小明  蒋伍玖  庾江喜
作者单位:衡阳师范学院化学与材料科学学院, 功能金属有机化合物湖南省重点实验室, 金属有机新材料湖南省普通高等学校重点实验室, 湘江上游重金属污染监测与治理湖南省工程研究中心, 衡阳 421008
基金项目:湖南省教育厅重点项目(No.19A070)、湖南省自然科学青年基金项目(No.2021JJ40010)、湖南省功能金属有机化合物重点实验室开放基金(No.2021HSKFJJ002)、湖南省应用特色学科基金、湖南省高校科技创新团队支持计划、国家级和湖南省大学生创新创业训练计划项目资助。
摘    要:合成了3个有机锡9-芴酮-4-甲酸酯:三苯基锡9-芴酮-4-甲酸酯(C6H5)3Sn(C14H7O3)](1)、三环己基锡9-芴酮-4-甲酸酯(C6H11)3Sn(C14H7O3)](2)和三(2-甲基-2-苯基丙基)锡9-芴酮-4-甲酸酯(C6H5C(CH3)2CH2)3Sn(C14H7O3)](3)。通过元素分析、红外光谱、核磁共振谱(1H、13C和119Sn)、热重分析进行了表征;用单晶X射线衍射方法测定了化合物的晶体结构,并对其进行了量子化学计算和体外抗...

关 键 词:三苯基锡9-芴酮-4-甲酸酯  三环己基锡9-芴酮-4-甲酸酯  三(2-甲基-2-苯基丙基)锡9-芴酮-4-甲酸酯  晶体结构  体外抗肿瘤活性
收稿时间:2022/11/22 0:00:00
修稿时间:2023/3/31 0:00:00

Synthesis, structure, and anticancer activity of organotin 9-fluorenone-4-carboxylates
ZHANG Fu-Xing,DENG Xin,YANG Zhe-Hao,ZHANG Xin,FU Kang-Xi,SHENG Liang-Bing,ZHU Xiao-Ming,JIANG Wu-Jiu,YU Jiang-Xi.Synthesis, structure, and anticancer activity of organotin 9-fluorenone-4-carboxylates[J].Chinese Journal of Inorganic Chemistry,2023,39(7):1287-1294.
Authors:ZHANG Fu-Xing  DENG Xin  YANG Zhe-Hao  ZHANG Xin  FU Kang-Xi  SHENG Liang-Bing  ZHU Xiao-Ming  JIANG Wu-Jiu  YU Jiang-Xi
Institution:Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China
Abstract:Three organotin 9 - fluorenone - 4 - carboxylate compounds, triphenyltin 9-fluorenone-4-carboxylate (C6H5)3Sn(C14H7O3)] (1), tricyclohexyltin 9-fluorenone-4-carboxylate (C6H11)3Sn(C14H7O3)] (2), and tri(2-methyl-2- phenylpropyl) tin 9-fluorenone-4-carboxylate (C6H5C(CH3)2CH2)3Sn(C14H7O3)] (3), were synthesized by the solvothermal method using methanol as a solvent. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (1H, 13C, and 119Sn), and thermogravimetric analysis. The crystal structures of the compounds were determined by single-crystal X-ray diffraction. The compounds were studied by quantum chemical calculation and in vitro anti- cancer activity. The results show that compound 1 has a 1D chain structure and the central tin atom is a five-coordinated distorted trigonal bipyramid configuration; compounds 2 and 3 are single tin nuclear molecules and the tin atoms are four-coordinated distorted tetrahedron configurations. The compounds have good inhibitory activity on the human cervical carcinoma cell line (HeLa), human liver cancer cell line (HUH-7), human non-small cell lung cancer cell line (A549), human lung adenocarcinoma cell line (H1975) and breast cancer cell line (MCF- 7).
Keywords:tricyclohexyltin 9-fluorenone-4-carboxylate  triphenyltin 9-fluorenone-4-carboxylate  tri (2-methyl-2-phenylpropyl) tin 9-fluorenone-4-carboxylate  crystal structure  in vitro antitumor activity
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