| 基于生物矿化的纳米载药体系 |
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| 引用本文： | 肖云,唐睿康.基于生物矿化的纳米载药体系[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 肖云 唐睿康 |
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| 作者单位： | 浙江大学化学系及生物物质与信息调控中心, 杭州 310027;浙江大学转化医学研究院, 杭州 310027,浙江大学化学系及生物物质与信息调控中心, 杭州 310027;浙江大学求是高等研究院, 杭州 310027 |
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| 基金项目： | 国家自然科学基金（No.21625105）和浙江省自然科学基金（No.Y17B010009）资助项目。 |
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| 摘 要： | 基于生物矿化的纳米载药体系具有制备简单、良好的生物相容性和控制药物释放的能力、易被修饰且具备多功能性和靶向性等优点，在临床中拥有巨大的应用前景。本文系统阐述了基于生物矿化的纳米载体的构建原理和分类，重点介绍了它们的靶向性策略和刺激响应释放策略，并展望了其在临床治疗中的应用。
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| 关 键 词： | 生物矿化 纳米 载药体系 磷酸钙 |
| 收稿时间： | 2017/7/20 0:00:00 |
| 修稿时间： | 2017/9/11 0:00:00 |
Nanoparticle Drug Delivery Systems Based on Biominaralization |
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| XIAO Yun and TANG Rui-Kang.Nanoparticle Drug Delivery Systems Based on Biominaralization[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | XIAO Yun and TANG Rui-Kang |
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| Institution: | Department of Chemistry and Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou 310027, China;Institute of Translational Medicine, Zhejiang University, Hangzhou 310027, China and Department of Chemistry and Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou 310027, China;Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Biominaralization based nanoparticle drug delivery systems that have the advantages of simple preparation, perfect biocompatibility, controlled drug release and easy to be modified have attracted a wide attention in field of clinical applications. This paper systematically elaborated the construction principle and classification of nanocarrier based on biomineralization, and the targeting strategy as well as stimulus response strategy of the caririers are discussed. The outlook of the clinical application is also prospected. |
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| Keywords: | biomineralization nanoparticle drug delivery calcium phosphate |
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