| 三个二（有机锡）吡啶-2,3（5）-二甲酸酯的合成、结构和体外抗癌活性 |
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| 引用本文： | 冯泳兰,庾江喜,蒋伍玖,朱小明,张复兴,邝代治.三个二（有机锡）吡啶-2,3（5）-二甲酸酯的合成、结构和体外抗癌活性[J].无机化学学报,2013,29(18). |
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| 作者姓名： | 冯泳兰 庾江喜 蒋伍玖 朱小明 张复兴 邝代治 |
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| 作者单位： | 衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008,衡阳师范学院化学与材料科学学院, 功能金属有机材料湖南省普通高等学校重点实验室, 衡阳 421008 |
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| 基金项目： | 湖南省高校创新平台开放基金（No.16K011，14K014）和湖南省自然科学基金（No.13JJ3112）资助项目。 |
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| 摘 要： | 在微波溶剂热中，三环已基氢氧化锡、氧化双（三（（2-甲基-2-苯基）丙基）锡）与吡啶-2，3（5）-二甲酸反应，合成了3个双核二（有机锡）吡啶-2，3（5）-二甲酸酯：Py（CO）2（SnR3）2（MeOH） n（R：Cy，n=1（1），2（2）；R：PhCMe2CH2，n=0（3）），对它们的组成和结构进行了元素分析、IR、（1H，13C，119Sn） NMR和X射线晶体衍射分析表征，化合物中心锡与配基原子构成畸形四/六面体构型，由于氢键作用，化合物1形成一维链，2形成二维34元大环网状结构。化合物对人结肠癌（HT-29）、肝癌细胞（HepG2）、乳腺癌（MCF-7）、鼻咽癌（KB）和肺癌细胞（A549）的增殖有较强的抑制作用。
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| 关 键 词： | 有机锡吡啶甲酸酯 微波溶剂热合成 体外抗肿瘤活性 |
| 收稿时间： | 2017/4/24 0:00:00 |
| 修稿时间： | 2017/10/26 0:00:00 |
Syntheses, Crystal Structures and in Vitro Antitumor Activity of Three Bis(organotin) Pyridine-2,3(5)-dicarboxylate |
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| FENG Yong-Lan,YU Jiang-Xi,JIANG Wu-Jiu,ZHU Xiao-Ming,ZHANG Fu-Xing and KUANG Dai-Zhi.Syntheses, Crystal Structures and in Vitro Antitumor Activity of Three Bis(organotin) Pyridine-2,3(5)-dicarboxylate[J].Chinese Journal of Inorganic Chemistry,2013,29(18). |
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| Authors: | FENG Yong-Lan YU Jiang-Xi JIANG Wu-Jiu ZHU Xiao-Ming ZHANG Fu-Xing and KUANG Dai-Zhi |
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| Institution: | Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China,Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China and Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China |
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| Abstract: | Three dinuclear bis(organotin) pyridine-2,3(5)-dicarboxylate, Py(CO)2(SnR3)2(MeOH)n (R:Cy, n=1 (1), 2 (2); R:PhCMe2CH2, n=0 (3)), have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide, bis(tri(2-methyl-2-phenyl)propyl)tin oxide with the pyridine-2,3(5)-dicarboxylic acid, respectively. The compounds are characterized by elemental analysis, IR, (1H, 13C, 119Sn) NMR spectra and X-ray crystallography diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. Compound 1 has a 1D supramolecular chain and 2 has a 2D network with 34-membered macrocyclic structure due to the coordinated methanol molecules via hydrogen bonds to the carbonyl oxygen atoms. The antitumor activity shows that these compounds have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro. |
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| Keywords: | organotin pyridine carboxylate microwave solvothermal synthesis in vitro antitumor activity |
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