| 叶酸受体靶向CdS量子点应用于HepG2细胞成像研究 |
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| 引用本文： | 张培根,余德才,程传伟,贺志鹏,张晓红,力虎林,张海黔.叶酸受体靶向CdS量子点应用于HepG2细胞成像研究[J].无机化学学报,2007,23(9):1662-1666. |
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| 作者姓名： | 张培根 余德才 程传伟 贺志鹏 张晓红 力虎林 张海黔 |
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| 作者单位： | 1. 南京航空航天大学材料科学与技术学院,医学物理系,南京,210016
2. 南京大学医学院附属鼓楼医院肝胆外科,南京,210008 |
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| 摘 要： | 0引言量子点(quantum dots,QDs)又称半导体纳米晶体(semiconductor nanocrystal),是一种由Ⅱ-Ⅵ族或Ⅲ-Ⅴ族元素组成的尺寸在2￣20nm之间,稳定的微
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| 关 键 词： | 量子点 表面修饰 细胞靶向 叶酸受体 生物成像 |
| 文章编号： | 1001-4861（2007）09-1662-05 |
| 修稿时间： | 2007-05-14 |
Folate-receptor Targeted CdS Quantum Dots for Identifying Tumor Cell HepG2 |
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| ZHANG Pei-Gen,YU De-Cai,CHENG Chuan-Wei,HE Zhi-Peng,ZHANG Xiao-Hong,LI Hu-Lin and ZHANG Hai-Qian.Folate-receptor Targeted CdS Quantum Dots for Identifying Tumor Cell HepG2[J].Chinese Journal of Inorganic Chemistry,2007,23(9):1662-1666. |
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| Authors: | ZHANG Pei-Gen YU De-Cai CHENG Chuan-Wei HE Zhi-Peng ZHANG Xiao-Hong LI Hu-Lin and ZHANG Hai-Qian |
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| Abstract: | High quality CdS quantum dots (CdS QDs) with a narrow size distribution have been synthesized through a reverse micelle route. Chemical modification and folate-functionalization of the QDs resulted in the bio-targeted fluorescent quantum dots(QDFs). Transmission electron microscopy (TEM) and photoluminescence emission spectroscopy were employed to characterize the morphologies and the optical properties of the QDs. Observation on the incorporation of QDFs with tumor cells (HepG2) under laser confocal fluorescent microscopy indicated that the QDFs could successfully identify the target tumor cells with high expression levels of folate receptor. |
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| Keywords: | quantum dots (QDs) surface modification cell-targeted folate-receptor bio-imaging |
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