以滤纸为模板合成新型介孔生物活性玻璃微管材料

用快速滤纸为生物模板,通过先浸渍后焙烧的方法合成了介孔生物活性玻璃微管材料。快速滤纸的管状结构被完美复制,其管壁为生成的介孔生物玻璃材料。通过在合成过程中引入铁元素可以使材料具有一定的磁性。材料的形貌、结构和磁性通过扫描电镜、粉末X射线衍射、透射电镜、氮气吸附-脱附曲线,红外光谱和磁滞回线进行了表征。并且通过模拟体液浸泡方法考察了其矿化能力,以地塞米松为模型药物考察其释药能力和生物相容性。合成的介孔生物活性玻璃微管材料具有复杂的管状多级结构、快速的矿化能力和良好的生物相容性,并具备一定的磁性,是一种不可多得的药物缓释材料。

Synthesis of Mesoporous Bioactive Glass Microtubes by Biotemplate of Filter Paper

Mesoporous bioactive glass microtubes were successfully prepared through a surface sol-gel process followed by a calcination treatment and using filter paper as the biotemplate. The tubular structures of rapid filter paper were replicated with the walls containing highly ordered mesoporous bioactive glasses as well. This simple biotemplate method provided a cost-effective and eco-friendly route to obtain advanced self-assembling mesoporous bioactive glass microtubes. By introducing FeCl₃, mesoporous bioactive glass microtubes had not only delicate multichannel tubular structures, but also magnetic properties. As-synthesized mesoporous bioactive glass microtubes were characterized by scanning electron microscope (SEM), powder X-ray diffraction (XRD), transmission electron microscope (TEM) and nitrogen adsorption/desorption, fourier transform IR (FTIR) spectroscopy, and magnetization curves. The in vitro mineralization ability of mesoporous bioactive glass microtubes was tested in SBF to monitor the formation of hydroxycarbonate apatite (HCA). Dexamethasone (DEX) was employed as a model drug and the release profiles showed that the porous materials had a sustained drug delivery capability. The one-dimensional hollow tubular structure of the materials allowed the shorter release time of the DEX. The materials of three-day release time could also be used as carriers for oral drug. The biocompatibilities were also evaluated by culturing the MC3T3-E1 cells on mesoporous bioactive glass microtubes. The results showed that the materials had excellent potential applications in the field of sustained drug delivery.