| 制备抗肿瘤药物庚铂的新方法 |
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| 引用本文： | 吴玉霞,陈永江,周云曙,袁开红,苟少华.制备抗肿瘤药物庚铂的新方法[J].无机化学学报,2004,20(2):215-218. |
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| 作者姓名： | 吴玉霞 陈永江 周云曙 袁开红 苟少华 |
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| 作者单位： | 1. 南京大学配位化学国家重点实验室,南京,210093
2. 江苏恒瑞医药股份有限公司 |
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| 摘 要： | Sunpla (SKI2053R), an anti-tumor drug in clinic use, has been prepared by a new method in which mercurous ions instead of silver ones were used to remove the coordinating halide anions from the intermediate, R(-NH2)2PtX2], and alkaline earth cations malonate or ammonium malonate were applied in the synthesis. The resulting platinum(Ⅱ) complex has been characterized with its IR, 1H-NMR and 13C-NMR, FAB-MS and TG-DTA spectra.
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| 关 键 词： | 庚铂 抗肿瘤药物 铂配合物 制备方法 波谱表征 |
| 修稿时间： | 2003年8月30日 |
A Novel Approach for Preparing the Anti-Tumor Drug: Sunpla |
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| WU Yu-Xi,CHEN Yong-Jiang,ZHOU Yun-Shu,YUAN Kai-Hong and GOU Shao-Hua.A Novel Approach for Preparing the Anti-Tumor Drug: Sunpla[J].Chinese Journal of Inorganic Chemistry,2004,20(2):215-218. |
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| Authors: | WU Yu-Xi CHEN Yong-Jiang ZHOU Yun-Shu YUAN Kai-Hong and GOU Shao-Hua |
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| Institution: | State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 |
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