| 各种金属卟啉催化环已烷的羟化作用 |
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| 引用本文： | 计亮年,刘敏,谢安康.各种金属卟啉催化环已烷的羟化作用[J].无机化学学报,1991,7(4):419-423. |
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| 作者姓名： | 计亮年 刘敏 谢安康 |
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| 作者单位： | 中山大学生物工程研究中心，中山大学生物工程研究中心，国立新加坡大学化学系 化学系，广州510275，化学系，广州510275，新加坡 |
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| 基金项目： | 国家自然科学基金，英国皇家化学会资助项目 |
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| 摘 要： | 金属卟啉、分子氧、抗坏血酸和底物构成细胞色素P450摸拟体系,实现了在常温常压下环已烷选择氧化为环已醇和环已酮,产品环已醇和环已酮是与金属卟啉周围取代基的类型密切相关,研究了中心金属离子,轴向配体,底物和催化剂的比例,以及pH对反应的影响,最后提出了金属卟啉活化分子氧的反应机理.
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| 关 键 词： | 环乙烷 金属卟啉 细胞色素 P450 |
| 收稿时间： | 1989/5/21 0:00:00 |
HYDROXYLATION OF CYCLOHEXANE CATALYZED BY VARIOUS METALLOPORPHYRINS |
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| Ji Liangnian,Liu Min and Hsich Ankang.HYDROXYLATION OF CYCLOHEXANE CATALYZED BY VARIOUS METALLOPORPHYRINS[J].Chinese Journal of Inorganic Chemistry,1991,7(4):419-423. |
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| Authors: | Ji Liangnian Liu Min and Hsich Ankang |
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| Institution: | Biotechnology Research Center, Department of Chemistry, Zhongshan University, Guangzhou 510275,Biotechnology Research Center, Department of Chemistry, Zhongshan University, Guangzhou 510275 and Department of Chemistry, National University of Singapore, Singapore |
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| Abstract: | The selective oxidation of cyclohcxane to cyclohexanol and cyclohcxanonc was realized in the model system of cytochrome P-450 consisting of mctalloporphyrins, molecular oxygen, ascorbic acid and substrate. The products, cyclohcxanol, and cyclohcxanonc were found to be sensitive to the peripheral substitution pattern of the mctalloporphyrins. The effects of the central metal ion, the axial ligand, the ratio of substrate to catalyst, and pH on the reaction were investigated and finally the reaction mechanism of the activation of molecular oxygen by the mctalloporphyrins was proposed. |
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| Keywords: | metalloporphyrin cytochrome P-450 cyclohexane |
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