| 多吡啶钴(Ⅲ)配合物与Zn2+形成的新型“关-开”荧光探针 |
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| 引用本文： | 张黔玲,刘剑洪,任祥忠,李翠华,张培新,刘建忠,计亮年.多吡啶钴(Ⅲ)配合物与Zn2+形成的新型“关-开”荧光探针[J].无机化学学报,2006,22(5):885-889. |
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| 作者姓名： | 张黔玲 刘剑洪 任祥忠 李翠华 张培新 刘建忠 计亮年 |
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| 作者单位： | 1. 深圳大学师范学院化生系,深圳,518060
2. 中山大学教育部基因工程重点实验室,广州,510275 |
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| 基金项目： | 广东省自然科学基金;广东省深圳市科技计划 |
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| 摘 要： | 近十几年来,对小分子过渡金属配合物与大分子DNA键合与识别机理的研究一直是国际上生物无机化学领域十分活跃的研究课题1￣3],已发展了一系列具有特定功能的配合物,如DNA结构探针和DNA荧光探针等。与其他类型的金属配合物相比,八面体过渡金属多吡啶配合物具有丰富的光化学和光物理信息,当这些配合物与DNA相互作用时,由于结构匹配或微环境的差异,配合物的光谱特征会出现不同程度的改变,从而达到对DNA的检测。传统的DNA荧光探针有Ru(bpy)2dppz]2 和Ru(phen)2dppz]2 (bpy=2,2′-联吡啶,phen=1,10-菲咯啉,dppz=二吡啶3,2-a∶2′,3′…
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| 关 键 词： | 多吡啶钴配合物 DNA Zn2+ 荧光 |
| 文章编号： | 1001-4861(2006)05-0885-05 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2006-03-13 |
A Newly Designed off-on Luminescent Probe Formed by Polypyridyl Cobalt(m) Complex and Zn2+ |
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| ZHANG Qian-Ling,LIU Jian-Hong,REN Xiang-Zhong,LI Cui-Hu,ZHANG Pei-Xin,LIU Jian-Zhong and JI Liang-Nian.A Newly Designed off-on Luminescent Probe Formed by Polypyridyl Cobalt(m) Complex and Zn2+[J].Chinese Journal of Inorganic Chemistry,2006,22(5):885-889. |
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| Authors: | ZHANG Qian-Ling LIU Jian-Hong REN Xiang-Zhong LI Cui-Hu ZHANG Pei-Xin LIU Jian-Zhong and JI Liang-Nian |
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| Institution: | Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, Guangdong 518060,Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, Guangdong 518060,Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, Guangdong 518060,Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, Guangdong 518060,Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen, Guangdong 518060,Key Laboratory of Gene Engineering of Ministry of Education, Zhongshan University, Guangzhou 510275 and Key Laboratory of Gene Engineering of Ministry of Education, Zhongshan University, Guangzhou 510275 |
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| Abstract: | The formation of heterobimetallic complex Co(bpy)2(ODHIP)Zn]5+ by Co(bpy)2ODHIP]3+ and Zn2+ was investigated. The luminescent property of complex was also studied. The results indicated that the nonluminescent monometallic complex Co(bpy)2ODHIP]3+ could coordinated with Zn2+ to form the luminescent heterobimetallic complex Co(bpy)2(ODHIP)Zn]5+, the emission intensity increased as increasing the amounts of Zn2+. The luminescence became the strongest at the ratio of CZn/CCo of 1. After binding to DNA, Co(bpy)2ODHIP]3+ must change its binding mode from partial intercalation to intercalation to make the peripheral coordination site on the ODHIP ligand accessible for Zn2+, the coordination occurred from the opposite side of helix with respect to the intercalated Co(bpy)2ODHIP]3+, and the luminescent heterobimetallic complex Co(bpy)2(ODHIP)Zn]5+ was formed. On the other hand, Co(bpy)2(ODHIP)Zn]5+ bound to DNA by intercalation and situated the region of the intercalated Co(bpy)2ODHIP]3+ between the base pairs of DNA, while the remained monometallic complex Co(bpy)2ODHIP]3+ bound to DNA by partial intercalation. |
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| Keywords: | polypyridyl cobalt complex DNA Zn2+ luminescence |
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