由4-甲基-1，2，3-噻二唑-5-甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用

以4-甲基-1,2,3-噻二唑-5-甲酸（C₄H₄N₂O₂S, HL）分别与硫酸钴（CoSO₄·7H₂O）、氯化铜（CuCl₂·2H₂O）、硝酸银（AgNO₃）反应合成了3个配合物Co（L）₂（H₂O）₄] ·2H₂O （1）、CuNa（L）₃] _n （2）和AgL] _n （3）,用元素分析、红外光谱、热重分析进行表征,用单晶X射线衍射测定了产物的结构。配合物1属于三斜晶系,空间群P1,Co²⁺的配位数为6,形成一个略为拉长的CoN₂O₄八面体,与理想的正八面体非常接近。配合物2属于三斜晶系,空间群P1。Cu²⁺离子的配位数为4,构成变形的平面四边形结构,Na⁺离子的配位数为6,构成一个略微变形的八面体结构,最终形成三维网状结构。配合物3属于单斜晶系,空间群P2₁/c,银离子为三配位,构成变形的平面三角形构型,具有二维网状结构。用溴化乙锭荧光探针法测定了配体和配合物与DNA作用的荧光光谱。

Syntheses, Crystal Structures and DNA Binding of Transition Metal Complexes Constructed by 4-Methyl-1,2,3-thiadiazol-5-carboxylic Acid

Three transition metal complexes Co(L)2(H₂O)4] ·2H₂O (1), CuNa(L)₃] _n (2) and AgL] _n (3) were synthesized from 4-methyl-1,2,3-thiadiazol-5-carboxylic acid(C₄H₄N₂O₂S, HL), CoSO₄·7H₂O, CuCl₂·2H₂O, and AgNO₃. They were characterized by elemental analysis, infrared spectrum, thermogravimetricanalysis (TGA). The crystal structures of the complexes were confirmed by single X-ray diffraction method. Complex 1 crystallizes in triclinic system with space group P1, Co²⁺ ion is six-coordinated to constitute a slightly deformation octahedral structure. Complex 2 crystallizes in triclinic system with space group P1. Cu²⁺ ion is four-coordinated to form a quadrilateral plane structure deformation, and Na⁺ ion is six-coordinated to constitute a slightly deformation octahedral structure, eventually forming a three-dimensional network structure. Complex 3 crystallizes in monoclinic system with space group P2₁/c, and its coordination number is three, forming a deformation plane triangle configuration with 2D network structure. In addition, DNA-binding of the ligand and complexes was studied by EtBr fluorescent probe method. CCDC: 1526276, 1; 1526277, 2; 1434529, 3.