| 吡啶甲酸铬衍生物的合成、安全性及降糖活性 |
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| 引用本文： | 柴杰,杨斌盛,刘斌.吡啶甲酸铬衍生物的合成、安全性及降糖活性[J].无机化学学报,2018,34(10):1783-1791. |
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| 作者姓名： | 柴杰 杨斌盛 刘斌 |
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| 作者单位： | 山西大学分子科学研究所化学生物学与分子工程教育部重点实验室 |
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| 基金项目： | 国家自然科学基金（No.21271122，21571117）资助项目。 |
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| 摘 要： | 合成了4种新型吡啶甲酸铬衍生物并通过单晶衍射、电喷雾质谱、元素分析、电导率及红外光谱等手段对其结构进行了表征。通过循环伏安法研究了配体对配合物氧化还原活性的影响,通过Fenton-like反应观察了配合物诱发产生自由基的程度,发现其中有3个配合物诱发产生的自由基少于市售产品吡啶甲酸铬Cr(pic)3。动物活体实验表明,高剂量配合物3不会对小鼠脏器造成明显损伤,低剂量喂食能降低糖尿病小鼠的空腹血糖及低密度脂蛋白,其效果优于Cr(pic)3。
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| 关 键 词： | 吡啶甲酸铬 氧化还原性 安全性 降糖活性 |
| 收稿时间： | 2018/4/7 0:00:00 |
| 修稿时间： | 2018/6/21 0:00:00 |
Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives |
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| CHAI Jie,YANG Bin-Sheng and LIU Bin.Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives[J].Chinese Journal of Inorganic Chemistry,2018,34(10):1783-1791. |
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| Authors: | CHAI Jie YANG Bin-Sheng and LIU Bin |
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| Institution: | Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China,Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China and Institute of Molecular Science, Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry, Shanxi University, Taiyuan 030006, China |
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| Abstract: | Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction, ESI-MS, analytical element, conductivity and IR analysis. The effect of substituent groups on its redox property and hydroxyl radical (·OH) generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction. As a result, three complexes generate less ·OH than Cr(pic)3. Besides, acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)3 in reducing fasten blood glucose (FBG) and low density lipoprotein by low dose. |
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| Keywords: | chromium picolinate redox property safety antihyperglycemic effects |
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