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| 新型三联吡啶铜配合物的晶体结构及DNA切割活性 | |
| 引用本文： | 姜 琴,施鹏飞,朱阳光,肖 楠,王大奇.新型三联吡啶铜配合物的晶体结构及DNA切割活性[J].无机化学学报,2009,25(4):589-595. |
| 作者姓名： | 姜 琴 施鹏飞 朱阳光 肖 楠 王大奇 |
| 作者单位： | 1. 淮海工学院化工系,连云港,222005 2. 淮海工学院化工系,连云港,222005;南京大学配位化学国家重点实验室,南京,210093 3. 南京大学配位化学国家重点实验室,南京,210093 4. 聊城大学化学化工学院,聊城,252059 |
| 基金项目： | 江苏省高校自然科学基金，淮海工学院自然科学基金 |
| 摘 要： | 本文合成了新型三联吡啶铜配合物Cu(ttpy)(acetone)Cl]·(NO3)(H2O)3(ttpy=4′-p-tolyl-2，2′∶6，2″-terpyridine)，通过元素分析和X-射线单晶衍射进行结构表征。该配合物属三斜晶系，空间群为P1，晶胞参数为a=0.847 6(3) nm，b=1.265 0(5) nm，c=1.422 7(5) nm,α=111.017(7)°，β=92.174(7)°,γ=90.562(7)°,V=1.422 5(9) nm3，Z=2，Dc=1.309 Mg·m-3，μ(Mo Kα)=9.00 cm-1，F(000)=578，R1=0.063 3,wR=0.141 4。在配合物中，中心铜原子的配位环境为变形四方锥，并通过分子内和分子间的C-H…Cl和C-H…O氢键作用形成三维梯状结构。凝胶电泳结果表明，在pH=7.4，温度37°，以抗坏血酸为还原剂的条件下，该配合物对超螺旋pUC19 DNA表现出一定的切割活性。紫外-可见光谱结果显示，该配合物与四种核苷的反应活性顺序为：5′-GMP>5′-AMP>5′-TMP≈5′-CMP。 |
| 关 键 词： | 三联吡啶铜配合物 晶体结构 DNA切割 |
Crystal Structure and DNA Nuclease Activity of a Copper(Ⅱ) Complex of 4'-p-Tolyl-2,2':6,2"-Terpyridine |
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| JIANG Qin,SHI Peng-Fei,ZHU Yang-Guang,XIAO Nan and WANG Da-Qi.Crystal Structure and DNA Nuclease Activity of a Copper(Ⅱ) Complex of 4''-p-Tolyl-2,2'':6,2"-Terpyridine[J].Chinese Journal of Inorganic Chemistry,2009,25(4):589-595. | |
| Authors: | JIANG Qin SHI Peng-Fei ZHU Yang-Guang XIAO Nan and WANG Da-Qi |
| Institution: | Department of Chemistry, Huaihai Institute of Technology, Lianyungang, Jiangsu 222005,Department of Chemistry, Huaihai Institute of Technology, Lianyungang, Jiangsu 222005; State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 and College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059 |
| Abstract: | A novel copper(Ⅱ)terpyridine complexCu(ttpy)(acetone)Cl]·(NO3)(H2O)3(ttpy=4'-p-tolyl-2,2':6,2"-terpyridine) had been synthesized and structurally characterized.The complex crystallized in the triclinic system,.space group P1- with cell parameters:a=0.8476(3)nm,b=1.2650(5)nm,c=1.4227(5),α=111.017(7)°,β=92.174(7)°, wR2=0.1414.The copper center was situated in a distorted square pyramidal(4+1)CuN3X2 coordination geometry with terpyriMine acting as an equatorial tridentate ligand.The 3D ladder-like structure was connected by intra-and concentration in the presence of ascorbic acid.The reactivity of the complex towards four mononucleotides with the order:5'-GMP>5'-AMP>5'.TMP≈5'-CMP,was determined by UV-Vis spectroscopy.CCDC:625295. |
| Keywords: | crystal structure DNA cleavage |
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