| 由2-甲基-4-噻唑甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用 |
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| 引用本文： | 张敏芝,武大令,沈伟,赵国良.由2-甲基-4-噻唑甲酸构筑的过渡金属配合物的合成、晶体结构及与DNA作用[J].无机化学学报,2018,34(12):2227-2237. |
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| 作者姓名： | 张敏芝 武大令 沈伟 赵国良 |
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| 作者单位： | 浙江师范大学化学与生命科学学院, 金华 321004,浙江师范大学化学与生命科学学院, 金华 321004,浙江师范大学化学与生命科学学院, 金华 321004,浙江师范大学化学与生命科学学院, 金华 321004;浙江师范大学行知学院, 金华 321004 |
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| 基金项目： | 浙江省公益性技术应用研究计划项目（No.2014C32014）资助。 |
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| 摘 要： | 以2-甲基-4-噻唑甲酸（HMTZA，C5H5NO2S）为配体合成了3种新型过渡金属配合物Co（MTZA）2（H2O）2]·3H2O（1），Cu（MTZA）2（H2O）]·2H2O（2）和Zn（MTZA）2（H2O）2]·3H2O（3）。对配合物进行了元素分析、红外光谱和热重分析表征，用单晶X射线衍射方法测定了配合物的晶体结构。结果表明，配合物1属于单斜晶系，空间群为P21/n，中心金属Co（Ⅱ）离子的配位数为6，配位构型为略为变形的八面体；配合物2属于三斜晶系，空间群为P1，Cu（Ⅱ）离子的配位构型是一个畸变的四方锥；配合物3属单斜晶系，空间群为P21/n，中心金属Zn（Ⅱ）离子的配位构型为畸变的八面体。用溴化乙锭荧光探针法测定了配体和配合物与DNA作用的荧光光谱，结果显示无论配体还是配合物均能使EB-DNA复合体系发生不同程度的荧光猝灭，且配合物的作用强度远大于配体。
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| 关 键 词： | 2-甲基-4-噻唑甲酸 过渡金属配合物 晶体结构 DNA作用 |
| 收稿时间： | 2018/6/5 0:00:00 |
| 修稿时间： | 2018/9/28 0:00:00 |
Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid |
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| ZHANG Min-Zhi,WU Da-Ling,Shen Wei and ZHAO Guo-Liang.Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid[J].Chinese Journal of Inorganic Chemistry,2018,34(12):2227-2237. |
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| Authors: | ZHANG Min-Zhi WU Da-Ling Shen Wei and ZHAO Guo-Liang |
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| Institution: | College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China,College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China,College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China and College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China;Xingzhi College, Zhejiang Normal University, Jinhua, Zhejiang 321004, China |
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| Abstract: | Three novel transition metal complexesCo(MTZA)2(H2O)2]·3H2O (1),Cu(MTZA)2(H2O)]·2H2O (2) andZn(MTZA)2(H2O)2]·3H2O (3) have been synthesized by using 2-methyl-4-thiazolecarboxylic acid (HMTZA,C5H5NO2S), structurally confirmed by single crystal X-ray diffraction method, and characterized by elemental analysis, IR analysis and TG. The single crystal X-ray diffraction reveals that complex 1 crystallizes in monoclinic system with space group P21/n. Central Co2+ is six-coordinated to constitute a slightly distorted octahedral structure. Complex 2 crystallizes in triclinic system with space group P1, and its coordination number is five, forming a slightly distorted pentahedral coordination geometry. Complex 3 crystallizes in monoclinic system with space group P21/n. Each Zn2+ is six-coordinated to constitute a distorted octahedral geometry. In addition, DNA-binding of the ligand and complexes were also studied by EtBr fluorescence probe. The interactions of complexes with DNA were stronger than the ligand. |
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| Keywords: | 2-methyl-4-thiazolecarboxylic acid transition metal complex crystal structure DNA-binding |
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